摘要
背景:异体器官移植是解决终末期器官衰竭最为有效的方法之一,有效克服移植排斥反应、成功诱导移植免疫耐受是器官移植亟待攻克的重大难题,临床目前所用免疫抑制药仍存在减轻慢性排斥反应作用有限、毒性大,易引发慢性感染和肿瘤等问题。近年来,间充质干细胞在器官移植后诱导的免疫耐受是当前研究的热点。目的:综述间充质干细胞的免疫调节特性及其在器官移植中应用的研究进展。方法:应用计算机检索CNKI数据库、PubMed生物医学数据库,中文检索关键词为"间充质干细胞;免疫调节;器官移植;排异反应;免疫耐受",英文检索关键词为"mesenchymal stem cells;immunomodulatory;organ transplantation;rejection reaction;immune tolerance"。纳入有关间充质干细胞免疫学特性及在器官移植中应用的论文报道和综述。结果与结论:从骨髓、脂肪、脐带、羊膜等多种组织分离而来的间充质干细胞,除了具有自我复制和多向分化潜能外,还具有低免疫原性和免疫调节特性,可以抑制T细胞、B细胞的增殖与活化;抑制NK细胞的增殖、细胞毒作用和细胞因子分泌;调节树突状细胞、巨噬细胞的功能活性,可诱导免疫耐受;在肾脏、肝脏、心脏和皮肤移植抗排斥反应的基础与临床研究中,显示了长期、良好的治疗效果和颇具潜力的应用前景。
BACKGROUND:Allogeneic organ transplantation is one of the most effective therapies to treat end-stage organ failure.However,it is an important problem to effectively overcome the transplantation reaction and induce the immune tolerance of transplantation.The current use of immunosuppressant drugs in clinical practice still has some problems such as limited effect on reducing chronic rejection and high toxicity,and causing chronic infection and tumor.In recent years,the immunomodulatory properties of mesenchymal stem cells have attracted attention in immune tolerance after organ transplantation.OBJECTIVE:To review the immunomodulatory properties of mesenchymal stem cells and their research progress in organ transplantation.METHODS:CNKI and PubMed databases were retrieved by using computer to search relevant articles about immunomodulatory properties of mesenchymal stem cells and their application in organ transplantation.The key words were“mesenchymal stem cells;immune regulation;organ transplantation;rejection reaction;immune tolerance”in Chinese and English,respectively.RESULTS AND CONCLUSION:Mesenchymal stem cells isolated from bone marrow,adipose tissue,umbilical cord,amniotic membrane and other tissues not only have self-replication and multidirectional differentiation potentials,but also have low immunogenicity and conspicuous immunomodulatory properties.Mesenchymal stem cells can inhibit the proliferation and activation of T cells and B cells,and inhibit the proliferation,cytotoxic effect and cytokine secretion of NK cells.Immune tolerance is induced by mesenchymal stem cells through regulating the function and activity of dendritic cells and macrophages.The basic and clinical researches have shown good long-term therapeutic effects and promising application prospect on the anti-rejection response to kidney,liver,heart and skin transplantation.
作者
蒋珊珊
王峰
余丽梅
Jiang Shanshan;Wang Feng;Yu Limei(Key Laboratory of Cell Engineering in Guizhou Province,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China;Biological Treatment Talent Base of Guizhou Province,Affiliated Hospital of Zunyi Medical University,Zunyi 563003, Guizhou Province,China;Department of Cardiovascular Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563003, Guizhou Province,China;Zunyi Stem Cell and Regenerative Medicine Engineering Center,Affiliated Hospital of Zunyi Medical University,Zunyi 563003, Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第1期103-109,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81660074)
项目负责人:王峰
贵州省科技重大专项(黔科合重大专项字[2011]6002)
项目负责人:余丽梅~~
