摘要
目的研究慢性阻塞性肺疾病(COPD)患者脑白质疏松及认知功能改变的情况。方法收集确诊为COPD的患者100例作为观察组,同时选取42例作为年龄-疾病对照组,两组均完善头颅MRI及认知功能评分,评估两组脑白质疏松及认知功能改变情况,同时进一步分析两组脑白质疏松部位的差异。结果观察组脑白质疏松比例较对照组明显升高(P <0.05),且认知功能损害明显(P <0.05);观察组认知功能损害以空间执行功能、言语能力、记忆力损害为主(P <0.05);观察组中深部白质损害出现比例明显高于对照组(P <0.05),侧脑室周围白质损害与对照组相差不明显(P> 0.05)。结论 COPD患者脑白质疏松及深部白质损害比例明显高于对照组,其执行功能、言语能力及记忆力较对照组下降明显。
Objective To investigate the effect of leukoaraiosis and cognitive impairment in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 100 patients with COPD were enrolled as observation group and 42 cases were selected as the age-disease control group.All patients were completed with cranial MRI and cognitive function scores in order to evaluate the leukoaraiosis and cognitive function.The difference regions between two groups of leukoaraiosis were also analyzed.Results The incidences of leukoaraiosis were significantly higher and the impairment of cognitive function is more obvious in the observation group compared to the control group(P<0.05);The impairment of cognitive function was mainly caused by spatial executive function,language ability and memory impairment in the observation group(P<0.05);The deep white matter lesions of the observation group was significantly higher than the control group(P<0.05)and there was no significant difference in the periventricular white matter lesions between the two groups(P>0.05).Conclusion The incidences of leukoaraiosis and deep white matter lesions are significantly higher in patients with COPD,with the executive function,language ability,memory decreased lower than the control group.
作者
闫俊
朱葛敏
屈晓一
柴旭兵
刘立平
叶楠
杨莹
曹团平
YAN Jun;ZHU Gemin;QU Xiaoyi;CHAI Xubing;LIU Liping;YE Nan;YANG Ying;CAO Tuanping(Department of neurology,Xi′an Fifth Hospital.Xi′an 710082,China)
出处
《实用医学杂志》
CAS
北大核心
2018年第21期3513-3516,3520,共5页
The Journal of Practical Medicine
基金
西安市科技局社会发展引导计划(编号:2017118SF/YX012)
陕西省自然科学基金(编号:2017SF-245)
