摘要
Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.
Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.
基金
Supported by a grant from the University of Malaya Research Grant RG448-12HTM of the Health and Translational Medicine Research Cluster to Esaki M Shankar
UM.C/625/1/HIR/Mo HE/MED/014 to Adeeba Kamarulzaman by the High Impact Research(HIR)
University of Malaya,SIDA SARC,VINNMER for Vinnova,Linkping University Hospital Research Fund,CALF and the Swedish Society of Medicine
the Swedish International Development Cooperation Agency
the Swedish Physicians against AIDS Research Foundation
the Swedish Research Council,Marie Larsson,No.AI52731
