摘要
目的评估老年直肠癌患者术前应用雷替曲塞与放疗联合治疗局部进展期直肠癌的远期疗效及安全性。方法老年局部进展期低位直肠腺癌患者46例,术前给予雷替曲塞化疗同步联合放疗。放疗结束后依据患者身体状况休息3～4周,行直肠癌根治术。结果临床完全消退患者3例(6.52%),无需手术治疗;根治性切除术患者43例,其中40例为保肛手术,实际保肛率86.96%。术后病理未见肿瘤细胞患者7例,为病理消退,总消退率为21.74%。36例患者肿瘤降期,占78.26%。5年无病生存率为65.22%,总生存率为71.74%。新辅助放化疗过程中4例患者出现3、4级不良反应,所有患者均未出现疾病进展、手术死亡。结论治疗老年局部进展期低位直肠癌患者术前应用雷替曲塞同步联合放疗疗效显著,且安全可靠。
Objective To evaluate the long-term efficacy and safety of raltitrexed combined with radiotherapy for locally advanced rectal cancer in elderly patients with rectal cancer.Method Forty-six elderly patients with locally advanced stage low rectal adenocarcinoma were treated with preoperative retretretroxed chemotherapy combined with radiotherapy.After the end of radiotherapy,3~4 weeks'rest was performed according to the patient's physical condition before radical resection of rectal cancer.Results Clinical complete regression was performed in 3 patients(6.52%),no longer need surgical treatment;Radical resection was performed in 43 patients,of whom 40 were anal sphincter preservation,and the actual anal preservation rate was 86.96%.Postoperative pathology showed no tumor cells in 7 patients,with a pathological regression and a total regression rate of 21.74%.In 36 cases,the tumor was descended,accounting for 78.26%.The 5 year disease-free survival rate was 65.22%,and the overall survival rate was 71.74%.During the neoadjuvant radiotherapy and chemotherapy,4 patients had grade 3 and 4 adverse reactions.All patients had no disease progression or operative death.Conclusion The treatment of elderly patients with locally advanced low rectal cancer with raltitrexed and concurrent radiotherapy is effective and safe.
作者
丁宁
秦越
陈艺
郭成业
DING Ning;QIN Yue;CHEN Yi;GUO Cheng-ye(Qingdao University,Qingdao,Shandong,266011;Department of Oncology,Qingdao Municipal Hospital,Qingdao,Shandong,266012)
出处
《临床普外科电子杂志》
2018年第3期1-5,共5页
Journal of General Surgery for Clinicians(Electronic Version)
关键词
老年
局部进展期
低位直肠癌
新辅助放化疗
疗效
Old people
Locally advanced
Low rectal cancer
Neoadjuvant radiotherapy and chemotherapy
Curative effect
