摘要
目的:了解痤疮丙酸杆菌对大环内酯-林可酰胺类抗生素交叉耐药和临床表型情况。方法:通过体外分离、培养、鉴定痤疮丙酸杆菌,使用琼脂稀释法进行体外药敏实验并使用韦恩图统计药敏交叉耐药数据结果。结果:156株痤疮丙酸杆菌对四种抗生素的药物敏感性试验中,17株对四种大环内酯-林可酰胺类抗生素全敏感,余139株对四种抗生素单一或多重耐药。其中二重耐药率为19. 4%(27/139),三重耐药率为5. 7%(8/139),四重耐药率高达28. 1%(39/139)。结论:东莞地区痤疮患者痤疮丙酸杆菌对大环内酯-林可酰胺类抗生素存在多重、交叉耐药,可能与大环内酯-林可酰胺类抗生素药物作用机理相似有关。
Objective:To investigate the antibiotic resistance and cross-resistance of Propionibacterium acnes to macrolide and lincosamides.Methods:Propionibacterium acnes were isolated,cultured and identified in vitro using agar dilution method.Venn diagram was used to calculate drug sensitivity and cross-resistance.Results:Susceptibilities to 4 antibiotics were tested in 156 strains of Propionibacterium acnes.Seventeen strains were sensitive to all tested antibiotics,while the rest resisted to either single or multiple antibiotics.The rates of secondary,triple and quadruple resistance were 19.4%(27/139),5.7%(8/139),and 28.1%(39/139),respectively.Conclusions:Propionibacterium acnes in acne patients in Dongguan display multiple cross-resistance to macrolide and lincosamides,possibly because these two drugs share same binding site.
作者
唐慧菁
阮建波
孙菲
谢嫦婷
朱瑞凊
李明
周涌
陈冬萍
TANG Hui-jing;RUAN Jian-bo;SUN Fei;XIE Chang-ting;ZHU Rui-qing;LI Ming;ZHOU Yong;CHEN Dong-ping(Department of Dermatology,Jinan University Medical School Affiliated Hospital of Dongguan,Dongguan 523899,China;Clinical of Laboratory,Jinan University Medical School Affiliated Hospital of Dongguan,Dongguan 523899,China;Department of Central Laboratory,Jinan University Medical School Affiliated Hospital of Dongguan,Dongguan 523899,China)
出处
《皮肤性病诊疗学杂志》
2018年第5期261-264,共4页
Journal of Diagnosis and Therapy on Dermato-venereology
基金
东莞市社会科技发展项目(编号:2013108101042)
关键词
痤疮丙酸杆菌
抗生素
交叉耐药
Propionibacterium acnes
antibiotic
cross-resistance
