摘要
目的探讨托伐普坦、托拉塞米两种药物在重症心力衰竭伴稀释性低钠血症治疗中的疗效。方法以单双号分组法将2014至2015年接受治疗的68例重症心力衰竭伴稀释性低钠血症患者分成对照组和观察组,每组34例。2组均行常规治疗的基础上,对照组予以托拉塞米,观察组予以托伐普坦。比较2组超声心动图参数、血液指标、治疗效果。结果 2组治疗前的四项心动图参数相比差异无统计学意义(P> 0. 05),疗程结束后,除E/A相比无统计学意义外,观察组其他三项指标更优,差异有统计学意义(P <0. 05)。治疗前2组五项血液指标差异无统计学意义(P> 0. 05),疗程结束后,2组血钾浓度比较差异无统计学意义(P> 0. 05),其他指标观察组优于对照组,差异有统计学意义(P <0. 05)。观察组重症心力衰竭治疗总有效率为94. 12%明显高于对照组的70. 59%,差异有统计学意义(P <0. 05)。观察组的稀释性低钠血症治疗总有效率为97. 06%高于对照组的73. 53%,差异有统计学意义(P <0. 05)。结论和托拉塞米相比,托伐普坦治疗重症心力衰竭伴稀释性低钠血症的效果更好。
Objective To investigate the curative effects of tolvaptan and torasemide on severe heart failure complicated by dilutional hyponatremia.Methods A total of 68 patients with severe heart failure complicated by dilutional hyponatremia who were treated in our hospital from 2014 to 2015 were divided into two groups according to odd and even numbers grouping method,with 34 patients in each group.On the basis of conventional treatment,the patients in control group were treated by oral torasemide,however,the patients in observation group were treated by oral tolvaptan.The echocardiography parameters,blood index and therapeutic effect were observed and compared between the two groups.Results There were no significant difference in the 4-item echocardiography parameters between the two groups(P>0.05).After treatment,there was no significant difference in E/A between the two groups(P>0.05),however the other three indexes in observation group were superior to those in control group(P>0.05).Before treatment there were no significant difference in the 5-item blood indexes between the two groups(P>0.05),after treatment there was no significant difference in the concentration of serum potassium between the two groups(P>0.05),however the other indexes in observation group were superior to those in control group(P<0.05).Moreover the total effective rate in treatment of severe heart failure in observation group was significantly higher than that in control group(94.12%vs 70.59%,P<0.05),and the total effective rate in treatment of dilutional hyponatremia in observation group was significantly higher than that in control group(97.06%vs 73.53%,P<0.05).Conclusion The tolvaptan has better curative effects on severe heart failure complicated by dilutional hyponatremia,as compared with those of torasemide.
作者
杨小东
王茜
刘东霞
赵海双
崔国旺
陈曦
王有余
YANG Xiaodong;WANG Qian;LIU Dongxia;ZHAO Haishaung;CUI Guowang;CHEN Xi;WANG Youyu(The Second Central hospital of Baoding City,Hebei,Baoding 071000,China)
出处
《河北医药》
CAS
2018年第21期3303-3305,3309,共4页
Hebei Medical Journal
