摘要
目的研究异丙托溴铵治疗哮喘伴慢性阻塞性肺疾病患者的临床效果。方法 128例哮喘伴慢性阻塞性肺疾病患者,根据治疗方法不同分为对照组和观察组,各64例。对照组给予常规对症支持治疗+布地奈德福莫特罗粉吸入治疗,观察组在对照组基础上给予异丙托溴铵吸入治疗,对比两组患者的治疗效果及肺功能指标。结果观察组患者总有效率为93.75%,对照组患者总有效率为81.25%,观察组患者总有效率显著高于对照组,差异具有统计学意义(χ~2=4.571, P=0.033<0.05)。治疗前,两组患者第1秒用力呼气容积(FEV1)、FEV1/占用力肺活量百分比(FEV1/FVC)、FEV1占预计值的百分比对比,差异无统计学意义(P>0.05);治疗4个疗程后,两组患者FEV1、FEV1/FVC、FEV1占预计值的百分比优于治疗前,且观察组患者FEV1、FEV1/FVC、FEV1占预计值的百分比高于对照组,差异具有统计学意义(P<0.05)。结论异丙托溴铵治疗哮喘伴慢性阻塞性肺疾病疗效确切,可促进患者支气管痉挛症状缓解,控制气道高反应性,改善肺功能,且用药方法简单,值得推广。
Objective To research the clinical effect of Ipratropium Bromide in the treatment of asthma complicated with chronic obstructive pulmonary disease.Methods A total of 128 asthma patients complicated with chronic obstructive pulmonary disease were divided into control group and observation group according to different treatment methods,64 cases in each group.The control group received conventional symptomatic supportive treatment plus inhalation of Symbicort Turbulaler.The observation group was given Ipratropium Bromide inhalation therapy on the basis of the control group.The therapeutic effect and pulmonary function indexes between the two groups were compared.Results The total effective rate of the observation group was 93.75%,and that of the control group was 81.25%.The total effective rate of the observation group was significantly higher than that in the control group,the difference was statistically significant(χ2=4.571,P=0.033<0.05).Before treatment,there were no significant differences in the forced expiratory volume in 1st second(FEV1),ratio of forced expiratory volume in 1st second to forced vital capacity(FEV1/FVC)and FEV1 percentage of estimated value between the two groups(P>0.05).After 4 courses of treatment,the FEV1,FEV1/FVC and FEV1 percentage of estimated value in the two groups were significantly better than those before treatment,and the FEV1,FEV1/FVC and FEV1 percentage of estimated value in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The efficacy of Ipratropium Bromide in the treatment of asthma complicated with chronic obstructive pulmonary disease is reliable,it can promote the remission of bronchospasm symptoms,control airway hyperresponsiveness,improve pulmonary function,and the medication method is simple,worthy of promotion.
作者
金晶雪
杨永胜
JIN Jing-xue;YANG Yong-sheng(First Department of Internal Medicine,The 406th Hospital of People’s Liberation Army,Dalian 116041,China)
出处
《中国现代药物应用》
2018年第20期68-69,共2页
Chinese Journal of Modern Drug Application
