摘要
目的:探讨大剂量氨甲环酸用于脊椎矫形及长节段固定手术的安全性和有效性。方法:收集2012年10月至2017年10月入院的80例行脊椎矫形及长节段固定手术患者随机分为两组,对照组患者遵循正常手术流程,氨甲环酸组患者则加用大剂量氨甲环酸,比较两组患者术中输血输液参数、Hb、HCT、疾病相关参数与并发症。结果:氨甲环酸组胶体输入量、自体红细胞、异体红细胞、新鲜冰冻血浆FFP、冷沉淀、血小板与总输液量均显著性低于对照组;术后1d Hb与HCT水平组间比较均显著性高于对照组;术毕APTT水平组间比较显著性低于对照组,PLT与血凝块时间均显著性高于对照组;术后输血率显著性低于对照组,存在显著性差异(P<0.01);低血压率明显低于对照组,存在明显差异(P<0.05)。结论:大剂量氨甲环酸用于脊柱矫形手术的临床效果显著,安全性较高,具有借鉴意义。
Objective:To investigate the safety and effectiveness of high dose tranexamic acid in spinal surgery.Methods:80 patients admitted to the hospital from October 2015 to October 2017 underwent spine orthopedic surgery were randomly divided into two groups.The patients in the control group followed the normal surgical procedures.Patients in the tranexamic acid group were treated with high doses of tranexamic acid The blood transfusion parameters,Hb,HCT,disease-related parameters and complication were compared between the two groups.Results:The amount of tranexamic acid,autologous erythrocytes,allogeneic red blood cells,fresh frozen plasma FFP,cryoprecipitate,platelets and total transfusion volume of tranexamic acid group were significantly lower than those of the control group.The levels of HCT and HCT at 1 day after operation were significantly higher Which was significantly higher than that of the control group.The APTT level at the end of surgery was significantly lower than that of the control group.The PLT and blood clot time were significantly higher than those of the control group.The postoperative blood transfusion rate was significantly lower than that of the control group(P<0.01).The rate of hypotension was significantly lower than that of the control group(P<0.05).Conclusion:High dose of tranexamic acid used in spinal surgery is clinically effective and safe,with reference value.
作者
时亮
段亮
董向辉
SHI Liang;DUAN Liang;DONG Xianghui(Shanxi People's Hospital,Shanxi Xi'an 710000,China)
出处
《河北医学》
CAS
2018年第10期1715-1719,共5页
Hebei Medicine
基金
陕西省卫生厅科研基金项目
(编号:2014JM41526)
