摘要
目的:评价MRI对胎儿结节性硬化症的诊断价值。方法:25例孕妇,24～39岁,平均26.4岁;孕龄22.3～35.0周,平均24.6周,产前超声发现胎儿心脏横纹肌瘤或其他畸形行MRI检查,将产前MRI诊断与出生后随访或引产后尸检结果对照,评估MRI对胎儿结节性硬化症的诊断价值。结果:25例孕妇,超声筛查发现心脏横纹肌瘤24例,腹裂1例,行MRI检查,产前MRI发现室管膜下结节6例,脑皮质结节3例,室管膜下结节伴皮质结节1例,室管膜下结节伴心脏横纹肌瘤8例,心脏横纹肌瘤2例,5例未发现阳性征象,18例产前诊断为结节性硬化症,均由出生后随访或引产后尸检证实,1例产前MRI诊断为心脏横纹肌瘤,产后诊断为TSC。结论:MRI对超声难以检出的胎儿脑内室管膜下及皮质下结节敏感,对结节性硬化病的产前诊断具有重要价值。
Objective:Evaluate the magnetic resonance imaging(MRI)in diagnosis of fetal tuberous sclerosis.Methods:25 pregnant women were recruited,from 24～39 years old with an average of 26.4 years,gestational age was 22.3 to 35.0 weeks,with an average of 24.6 weeks.Prenatal ultrasound found fetal rhabdomyomas or other malformations,the underwent MRI.The prenatal MRI diagnosis was compared with postnatal follow-up or autopsy results after induction of labor,in order to evaluate the diagnostic value of MRI for fetal tuberous sclerosis.Results:Of 25 pregnant women,ultrasound screening revealed 24 with cardiac rhabdomyoma,1 with abdominal fissure.Prenatal MRI examination found 6 cases with subependymal nodules,3 cases with cerebral cortical nodules,1 case with subependymal nodules with cortical nodules,8 cases with the subependymal nodules with cardiac rhabdomyoma,2 cases with cardiac rhabdomyoma,the other 5 cases negative.Prenatal diagnosis of tuberous sclerosis in 18 cases,which were confirmed by autopsy or after birth follow up study,1 case with cardiac rhabdomyoma,postpartum diagnosis of TSC.Conclusion:Fetal MRI is sensitive to detect the subventricular and subcortical nodules in fetal brain,which is difficult to detect by ultrasound,indicating having great value in diagnosis of fetal tuberous sclerosis.
作者
庄严
王添平
常卓琳
张国福
ZHUANG Yan;WANG Tian-ping;CHANG Zhuo-lin(Department of Radiology,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)
出处
《放射学实践》
北大核心
2018年第10期1068-1072,共5页
Radiologic Practice
基金
上海市市级医院新兴前沿技术联合攻关项目(SHDC12014130)
关键词
胎儿
结节性硬化症
磁共振成像
Fetus
Tuberous sclerosis
Magnetic resonance imaging
