摘要
目的:探讨增强CT后对比剂相关急性肾损伤(PC-AKI)的发生率与对比剂肾病(CIN)各相关危险因素的相关性。方法:回顾性分析3021例患者在CT增强扫描前后内血清肌酐值的变化,比较CIN和急性肾损伤(AKI)的发生率以及各危险因素(性别、年龄、糖尿病、高血压、心脏疾病、肾脏疾病、泌尿系结石和/或梗阻性肾、输尿管积水、肾脏肿瘤、先天性肾疾病、肾脏手术、升主动脉或心脏手术、化疗、放疗)在PC-AKI与非PC-AKI患者两组间的差异。结果:CIN发生率为7.4%,AKI发生率为4.3%。患肾肿瘤(P<0.001)、需要进行肾脏手术(P<0.001)、升主动脉或心脏手术(P=0.020)的患者CIN发生率更高,化疗患者的CIN发生率降低(P=0.027)。AKI与非AKI患者进行比较,分布情况与CIN类似,但AKI患者中男性比例稍高(P<0.001),平均年龄稍大(P=0.031)。结论:行增强CT检查的住院患者PC-AKI的发生率较低,PC-AKI的发生率与肾脏及心血管相关危险因素呈正相关性,与化疗呈负相关性。
Objective:The purpose of this study was to investigate the incidence of post-contrast acute kidney injury(PC-AKI)of CT scan and its correlation with risk factors associated with contrast-induced nephropathy(CIN).Methods:The changes of serum creatinine(SCr)values of 3021 patients before and after enhanced CT scan were analyzed retrospectively.The incidence rate of CIN and AKI were compared.The difference of risk factors(age,gender,diabetes mellitus,hypertension,heart disease,renal disease,urinary stone with or without obstructive hydronephrosis,renal tumor,congenital renal disease,renal surgery,ascending aortic or cardiac surgery,chemotherapy,radiotherapy)was also compared between the two groups with and without PC-AKI.Results:The incidence rate of CIN was 7.4%and AKI was 4.3%.Patients with suspected renal tumors(P<0.001),renal surgery(P<0.001),and ascending aortic or cardiac surgery(P=0.020)had more possibility to suffer CIN;however,patients with chemotherapy had less possibility(P=0.027).The incidence of AKI was similar compared with Non-AKI,but AKI group had less female patients(P<0.001)and slightly higher average age(P=0.031).Conclusion:The incidence rate of PC-AKI is relatively less in in-patients when undergoing iodinated enhanced CT examinations.It is positively correlated with renal and cardiovascular risk factors,and negatively correlated with chemotherapy.
作者
马丽娅
李震
沈亚琪
胡道予
MA Li-ya;LI Zhen;SHEN Ya-qi(Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《放射学实践》
北大核心
2018年第9期918-922,共5页
Radiologic Practice
基金
同济医院科研基金(2201101680)
国家自然科学基金(81571642
81701657
81771801)
中央高校基本科研业务费专项资金资助(NO.2017KFYXJJ126)
关键词
对比剂相关急性肾损伤
对比剂肾病
碘对比剂
增强CT
体层摄影术
X线计算机
Post-contrast acute kidney injury
Contrast induced nephropathy
Iodinated contrast agent
Enhanced CT
Tomography,X-ray computed
