摘要
目的研究持续血液灌流(HP)对急性百草枯中毒(APP)患者血浆Presepsin及其他炎症因子水平、氧化应激损伤指标的影响。方法选取该院收治的APP患者92例,分成对照组和治疗组,分别于治疗前及治疗后3 d检测MDA、SOD、TNF-α及IL-6水平;治疗前及治疗后6、12和24 h检测血Presepsin及百草枯(PQ)浓度,并进行分析。结果两组患者治疗前MDA、SOD、TNF-α及IL-6水平比较无差异(P>0.05);两组患者治疗后MDA、SOD、TNF-α及IL-6水平比较有差异(P<0.05)。两组患者血浆Presepsin、PQ水平比较有差异(P<0.05)。APP患者治疗前血浆Presepsin水平与PQ浓度呈正相关(P<0.05)。治疗后24 h,血浆Presepsin水平与PQ浓度无相关性(P>0.05)。结论持续HP可减低APP患者血浆Presepsin及其他炎症因子水平,减轻氧化应激损伤,改善预后。
Objective To study the effect of continuous hemoperfusion on plasma presepsin,inflammatory factor levels and oxidative indexes in the patients with acute paraquat poisoning(APP).Methods Ninety-two cases of APP were randomly divided into a control group and a treatment group.Before treatment and 3 d after treatment,the levels of malondialdehyde(MDA),serum superoxide dismutase(SOD),tumor necrosis factor-α(TNF-α),and interleukin 6(IL-6)were detected.Before treatment and 6,12 and 24 h after treatment,presepsin and blood plasma paraquat concentration were detected.The results were compared between the two groups.Results There was no difference in the level of SOD,MDA,TNF-αor IL-6 between the two groups before treatment(P>0.05),but there were significant differences in the levels of SOD,MDA,TNF-αand IL-6 between the two groups after treatment(P<0.05).There was no difference in plasma presepsin or paraquat concentration between the two groups before treatment(P>0.05).The plasma paraquat concentration decreased gradually at 12 and 24 h after treatment,and the difference between the two groups was statistically significant(P<0.05).The plasma presepsin level increased at 12 and 24 h after treatment,the difference was statistically significant between the two groups(P<0.05).There was a positive correlation between plasma presepsin level and paraquat concentration in the patients with APP before treatment(P<0.05).There was no correlation between plasma presepsin level and paraquat concentration 24 h after treatment(P>0.05).Conclusions Continuous hemoperfusion therapy can decrease the levels of plasma presepsin and inflammatory factors,reduce oxidative stress injury and improve the prognosis of the patients with APP.The level of presepsin in plasma can be used to evaluate the condition of the patients and guide the clinical treatment.
作者
高珣
李敬
王维展
肖青勉
叶艳巧
Xun Gao;Jing Li;Wei-zhan Wang;Qing-mian Xiao;Yan-qiao Ye(Harrison International Peace Hospital Affiliated to Hebei Medical University,Hengshui,Hebei 053000,China)
出处
《中国现代医学杂志》
CAS
2018年第26期79-83,共5页
China Journal of Modern Medicine
基金
河北省科技计划项目(162777109D)
