摘要
目的: 探讨滋肾活血方联合厄贝沙坦片用药在早期糖尿病肾病患者中的临床疗效。方法: 选取60例糖尿病肾病患者随机分为对照组和治疗组各30例。对照组采用基础治疗加厄贝沙坦片,治疗组在此基础上加用滋肾活血方颗粒剂,对比两组疗效。结果:治疗组综合疗效及中医证侯疗效均显著高于对照组(P<0.05),两组患者血糖血脂水平、UAER、a_1-MG、β_2-MG及TGF-β_1均得到显著改善(P<0.05),除总胆固醇、a_1-MG外,其余各指标治疗组改善程度显著优于对照组(P<0.05)。结论: 滋肾活血方联合厄贝沙坦片用药较单独厄贝沙坦片用药治疗早期糖尿病肾病具有更好效果。
Objective:To explore the clinical effects of Zishen Huoxue decoction plus irbesartan tablets for the treatment of early diabetic nephropathy(DN).Methods:Sixty DN patients were selected and divided into a control group(n=30)and a treatment group(n=30).The control group was treated with routine therapy and irbesartan tablets while the treatment group was additionally treated with Zishen Huoxue decoction besides the therapy in the control group.The clinical effects were compared between the two groups.Results:After treatment,the comprehensive curative effect and the efficacy of TCM syndromes was significant better in the treatment group than the control group(P<0.05).The levels of blood sugar,cholesterol UAER,a1-MG,β2-MG and TGF-β1 were all improved in the two groups and the improvement of these indexes other than total cholesterol and a1-MG was more significant in the treatment group than the control group(P<0.05).Conclusion:Zishen Huoxue decoction plus irbesartan tablets for the treatment of early diabetic nephropathy possesses better effect compared with irbesartan tablets alone.
作者
车卫平
时蔡林
王国斌
CHE Weiping;SHI Cailin;WANG Guobin(Department of Nephrology,Jiujiang Hospital of TCM,Jiangxi Jiujiang 332000,China)
出处
《上海医药》
CAS
2018年第17期33-36,共4页
Shanghai Medical & Pharmaceutical Journal
基金
江西省卫生计生委中医药科研课题(2015B034)
关键词
糖尿病肾病
厄贝沙坦片
滋肾活血方
diabetic nephropathy
irbesartan tablets
Zishen Huoxue decoction