摘要
目的探讨宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)Ⅰ级合并高危型HPV感染行宫颈环形电切术(loop electrosurgical excision procedure,LEEP)与聚焦超声治疗的疗效对比。方法分析2015年2月—2017年10月在我院治疗的CINⅠ级患者67例,据患者选取的治疗方案分为LEEP组和超声组,LEEP组给予LEEP治疗,超声组给予聚集超声治疗,观察2组疗效,同时检测手术前后炎性因子水平。结果超声组阴道出血量、出血时间、排液量、排液时间和宫颈创面愈合时间分别为(7.50±1.30)ml、(5.55±1.83)d、(9.89±1.90)ml、(6.51±1.15)d和(4.01±1.15)周,明显少于LEEP组(P均<0.05);超声组和LEEP组治疗有效率分别为87.50%和91.43%,差异无统计学意义(P>0.05);超声组和LEEP组治疗后HPV转阴率分别为93.75%和94.29%,差异无统计学意义(P>0.05);结论 LEEP和聚焦超声治疗CINⅠ级合并高危型HPV感染均有较好的效果,但聚焦超声治疗术后阴道排液、出血情况轻,宫颈创面愈合快。
Objective To investigate and compare the therapeutic effect of loop electrosurgical excision procedure on cervical intraepithelial neoplasia(gradeⅠ)combined with high-risk HPV infection with focused ultrasound.Methods Sixtyseven CINⅠpatients were selected from February 2015 to October 2017 in our hospital and they were divided into LEEP group and ultrasound group.LEEP group was treated with LEEP,and ultrasound group was treated with focused ultrasound.Therapeutic effect was observed.The levels of inflammatory factors before and after surgery were detected.Results The vaginal bleeding volume,bleeding time,drainage volume,drainage time and the time of cervical wound closure in the ultrasound group were(7.50±1.30)ml,(5.55±1.83)d,(9.89±1.90)ml,(6.51±1.15)d and(4.01±1.15)weeks,which were significantly shorter than those in the LEEP group(P<0.05);The effective rate of treatment in the ultrasound group and the LEEP group were 87.50%and 91.43%,respectively,and the difference was not statistically significant between 2 groups(P>0.05).The HPV negative rates in the ultrasound group and the LEEP group were 93.75%and 94.29%,respectively,and the difference was not statistically significant in 2 groups(P>0.05).Conclusions LEEP and focused ultrasound treatment are both effective in treatment of gradeⅠCIN combined with high-risk HPV infection.Moreover,focused ultrasound reduces vaginal discharge and bleeding and accelerates cervical wound healing.
作者
林琳
傅亚均
LIN Lin;FU Ya-jun(Department of Gynaecology and Obstetrics,the First People's Hospital of Chongqing Liangjiang New Area,401121,China)
出处
《传染病信息》
2018年第4期368-371,共4页
Infectious Disease Information
关键词
宫颈上皮内瘤变
高危型HPV
宫颈环形电切术
聚焦超声
临床疗效
cervical intraepithelial neoplasia
high-risk human papillomavirus
cervical loop electrosurgical excision procedure
focused ultrasound
clinical efficacy
