摘要
为探究谷红注射液抗脑缺血分子机制,采用大脑中动脉阻塞建脑缺血模型,评价谷红注射液抗脑缺血药效,并采用网络药理学分析其分子机制。谷红注射液有良好抗脑缺血作用,主要通过红花黄素A、γ-氨基丁酸等131个成分调控氨基酸代谢、钙信号通路等12条通路,作用AGT、IL8等64个核心靶点而发挥作用。谷红注射液网络药理学分析揭示其抗脑缺血的物质基础、作用通路及靶点,为其深入研究提供一定的理论依据。
To investigate molecular mechanism of Guhong injection against rat cerebral ischemia-reperfusion injury,Middle Cerebral Artery Occlusion(MCAO)was adopted to evaluate the protection of Guhong injection against cerebral ischemia-reperfusion injury,and a network pharmacology approach was applied to investigate molecular mechanism of Guhong injection against cerebral ischemia-reperfusion injury.Guhong injection demonstrated effective protectionagainst cerebral ischemia-reperfusion injury was demonstrated.Based on the network pharmacology analysis,131 compounds such as canthaxanthin A,γ-aminobutyric acid,regulated 12 functional pathways like amino acid metabolism,calcium signaling pathway,and had an effect on 64 key targets such as AGT,IL8 which was related with the Guhong injection-mediated protection.In this study,the network pharmacological analysis of Guhong-mediated protection provides potential clues for further research on the material basis and molecular mechanism.
作者
范芳芳
陈舒曼
杨洪军
张艺
唐仕欢
李德风
张毅
张晶晶
高金环
FAN Fangfang;CHEN Shuman;YANG Hongjun;ZHANG Yi;TANG Shihuan;LI Defeng;ZHANG Yi;ZHANG Jingjing;GAO Jinhuan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;College of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 111137,China)
出处
《复杂系统与复杂性科学》
EI
CSCD
2018年第1期11-17,共7页
Complex Systems and Complexity Science
基金
国家自然科学基金(81603422)
国家科技支撑计划课题(2011BAI07B08)
四川省属高校科研创新团队建设计划项目(11TD004)
关键词
谷红注射液
脑缺血再灌注
网络药理学
分子机制
Guhong injection
cerebral ischemia-reperfusion
network pharmacology
molecular mechanism
