摘要
帕金森病是一种慢性进行性的神经变性疾病,主要临床表现包括运动迟缓、肌强直、静止性震颤和姿势平衡障碍等运动症状及嗅觉减退、睡眠障碍、认知障碍、情绪障碍等非运动症状。褪黑素是一种主要由松果体合成的激素,具有调节昼夜节律、清除自由基、抗氧化、抗炎症、神经保护等多种作用。当机体褪黑素分泌节律紊乱时易发生多种神经变性疾病,如阿尔茨海默病、帕金森病。帕金森病与脑内褪黑素含量及受体的表达受损有关。外源性褪黑素能改善帕金森病的运动症状,同时对睡眠障碍、认知障碍、焦虑和抑郁等也显示出现一定的作用。本文概括了褪黑素能系统在帕金森病发病和治疗中的潜在作用。
Parkinson′s disease is a chronic progressive neurodegenerative disease.The main clinical manifestations include motor syptoms such as bradykinesia,tremor,rigidity,and postural instability,as well as non-motor symptoms,such as impaired olfaction,sleep disorder,cognitive impairment,and emotional disorder.Melatonin is a hormone synthesized mainly by the pineal gland,regulating the circadian rhythm.Besides it acts as a free-radical scavenger,with neuroprotective,anti-inflammatory,and antioxidant properties.The unbalance of pineal melatonin synthesis disposes the body to a variety of neurodegenerative diseases,including Alzheimer's disease and Parkinson′s disease.Parkinson′s disease is due to the impairment of melatonin concentration and the expression of its receptor in the brain.Exogenous melatonin treatment improves its motor symptoms.Besides,it also shows effects on non-motor symptoms,such as sleep disorders,congnitive disorders,anxiety and depression.The aim of this review is to summarize the knowledge about the potential role of the melatoninergic system in the pathogenesis and treatment of Parkinson′s disease.
作者
胡莹莹
汪锡金
HU Yingying;WANG Xijin(Department of Neurology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University Medical College,Shanghai 200092,China)
出处
《中国医药导报》
CAS
2018年第21期23-26,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81671273)
