摘要
目的探讨老年食管癌患者合并焦虑情绪对围手术期血清髓过氧化物酶(MPO)、血清脂氧素A4(LXA4)水平及血管内皮功能的影响。方法选取2015年10月-2016年10月该院所收治的60例老年食管癌合并焦虑情绪患者作为研究对象,并将其随机分为观察组和对照组,每组各30例。两组均行食管癌根治性手术治疗,观察组在手术治疗基础上加抗焦虑干预治疗。比较和分析两组焦虑情绪、血清MPO、血清LXA4及血管内皮功能变化情况;治疗后6个月预后情况和观察组治疗后不同焦虑自评量表评分(SAS)与血清MPO、LXA4水平及血管内皮功能变化情况。结果两组治疗后SAS比较有差异(P<0.05),观察组SAS低于对照组;两组治疗后血清MPO比较有差异(P<0.05),观察组血清MPO低于对照组;两组治疗后血清LXA4比较有差异(P<0.05),观察组血清LXA4低于对照组;两组治疗后内皮素(ET)比较有差异(P<0.05),观察组低于对照组;两组治疗后一氧化氮(NO)、血管扩张率(FMD)及动脉内径变化率(GTN)比较有差异(P<0.05),观察组高于对照组;观察组治疗后不同SAS评分与血清MPO、LXA4水平及血管内皮功能指标变化情况比较有差异(P<0.05);两组治疗后6个月预后情况比较有差异(P<0.05),观察组预后情况优于对照组(P<0.05)。结论抗焦虑干预治疗能有效消除老年食管癌患者合并焦虑的负性情绪,改善患者围手术期血清MPO、LXA4水平及血管内皮功能,可作为理想的辅助治疗方案在临床应用和推广。
Objective To investigate the effect of perioperative anxiety on serum MPO,LXA4 and vascular endothelial function for elderly patients with esophageal cancer.Methods Totally 60 elderly patients with esophageal cancer combined anxiety admitted into our hospital from October 2015 to October 2016 were involved in this study.Patients were randomly divided into observation group and control group(n=30).All patients received standard radical surgery.Additional anti-anxiety therapy was introduced in observation group.The changes of anxiety,serum levels of MPO,LXA4,vascular endothelial function,and the prognosis of 6 monthspre andpost treatment were recorded.Results Patients in observation group experienced significantly decreased levels of SAS score,MPO,LXA4 and ET when compared with control group(P<0.05),while concentrations of NO,FMD and GTN were increased significantly in observation group when compared with that in control group(P<0.05).Treatment of anxiety induced dramatically decrease of SAS score,MPO and LXA4 as well as improved prognosis when compared with that prior to any anti-anxiety intervention.Conclusions Anti-anxiety intervention eliminates perioperatively negative emotions and improve prognosis of elderly patients with esophageal cancer combined with anxiety.
作者
郝雁冰
王丽
容宇
魏东
李彦明
陈万生
Yan-bin Hao;Li Wang;Yu Rong;Dong Wei;Yan-ming Li;Wan-sheng Chen(Department of Thoracic Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Anesthesiology,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《中国现代医学杂志》
CAS
2018年第21期68-73,共6页
China Journal of Modern Medicine
