摘要
目的:评价门诊使用的两种方案治疗失眠症的药物经济学效果,为治疗失眠症患者合理使用失眠药提供客观依据。方法:根据《中国成人失眠诊断与治疗指南》失眠诊断标准,将87例患者随机分为试验组(n=45)和对照组(n=42),试验组口服酒石酸唑吡坦10mg/d,对照组口服阿普唑仑片为0.4mg/d,入睡前连续服用7d,比较其疗效及不良反应发生率,并进行成本-效果分析。结果:两组方案的有效率分别为77.78%,73.81%,两组临床疗效比较(P>0.05)无显著性差异;两组常见的不良反应发生率(P>0.05)无显著性差异,治疗药物成本分别试验组23.9元和对照组0.63元。结论:酒石酸唑吡坦片与阿普唑仑均能有效治疗失眠症,但酒石酸唑吡坦片的治疗方案成本-效果较低,具有药物经济学优势。
Objective To evaluate the pharmacoeconomic efficacy of two kinds of regimens used in outpatient department of our hospital for the treatment of insomnia,and to provide an objective basis for the rational use of insomnia in treating patients with insomnia.Methods:According to guidelines for the diagnosis and treatment of adult insomnia in China,the patients were randomly divided into two groups,a group of treatment group with Zolpidem Tartrate tablets 10mg/d,and a group of control group with Alprazolam 0.4mg/d.After seven-days administration before going to sleep,efficacy evaluation and the rate of adverse effect of the use of SDRS score were compared.And the cost effectiveness was analyzed.Results:The effective rate of the two groups respective were 77.78%,73.81%;The effective rate had no significant difference between two groups(P>0.05);Adverse drug reaction had no significant difference between two groups(P>0.05);The average cost in the Zolpidem Tartrate tablets group was 23.9 yuan,and the Alprazolam group was 0.63 yuan.Sensitivity analysis revealed that the results were not sensitive to changes in the drug cost.Conclusion:Both Zolpidem Tartrate tablets and Alprazolam tablets are available for insomnia,but more advantage of Alprazolam tablets in the cost-effectiveness.
作者
李秀荣
于楠
LI Xiurong;YU Nan(Shijingshan Teaching Hospital of Capital Mecical University Medical College,Beijing 100043,China)
出处
《河北医学》
CAS
2018年第7期1201-1204,共4页
Hebei Medicine
关键词
阿普唑仑片
思诺思片
失眠症
Alprazolam tablets
Zolpidem tartrate tablets
Insomnia
