摘要
目的了解辅助生殖技术(Assisted reproductive technology,ART)受孕儿新生儿期疾病特点,并对影响ART受孕儿神经发育预后因素进行研究。方法随机选择2015年1月~2017年6月某三级甲等妇幼保健院新生儿重症监护室及新生儿科住院的ART受孕儿80例作为研究组,另随机选取同期住院的自然受孕儿(Natural conception,NC)80例作为对照组,采用问卷调查法收集两组新生儿期疾病情况,比较两组主要疾病构成的差异;参照婴幼儿智能发育量表(Canadian derivatives clearing corporation,CDCC)将ART受孕儿分为神经行为发育异常组和正常组,对影响ART受孕儿神经发育的因素进行Logistic回归分析。结果研究组患儿脑白质损伤、呼吸窘迫综合征(Newborn respiratory distress syndrome,NRDS)、颅内出血的比例显著高于对照组(P<0.05);"胎龄<32周"、"极低出生体重"、"多胎"是影响ART受孕儿神经发育预后的主要因素(P<0.05)。结论 ART受孕儿患脑白质损伤、NRDS、颅内出血比例较高,影响其神经发育预后的主要因素有"极低出生体重"、"胎龄<32周"、"多胎",应降低多胎发生率,并加强对极低出生体重及低胎龄儿的干预,以降低疾病发生概率,提高神经发育预后。
Objective To study the neonatal diseases’features of infants born after assisted reproductive technology(ART)and explore the neurodevelopment prognosis influencing factors.Methods 80 infants born after ART were randomly selected as study group from Neonatal ICU and newborn pediatrics department in a first class maternal and child healthcare hospital from January 2015 to June 2017.80 cases of naturally conceived(NC)infants from the same period of hospitalization were selected as control group.By the means of questionnaire to collect the information of diseases in control group and study group,we compared the composition of diseases in the two groups.The group of ART was divided into neurobehavioral abnormalities group and normal group by Canadian Derivatives Clearing Corporation(CDCC).Logistic Regression analysis was used to find the neurodevelopment prognosis influencing factors.Results The incidence rates of cerebral white matter injury,newborn respiratory distress syndrome(NRDS)and intracranial hemorrhage of the study group were significantly higher than those of the control group(P<0.05).“Gestational age<32 weeks”,“very low birth weight”and“multiple births”are the main risk factors of neurodevelopment prognosis(P<0.05).Conclusion The ratios of cerebral white matter injury,NRDS and intracranial hemorrhage were relatively high and the main risk factors of neurodevelopment prognosis were“Gestational age<32 weeks”,“very low birth weight”and“multiple births”.Decreasing the incidence of multiple births and enhancing the prevention of infants with very low birth weight or low age should be done to reduce the incidence of diseases and improve neurodevelopment prognosis.
作者
白敏
韩宜姚
徐巧
BAI Min;HAN Yiyao;XU Qiao(Department of Pediatrics,Zhoushan Maternity and Infant Hospital in Zhejiang Province,Zhoushan 316000,China)
出处
《中国现代医生》
2018年第16期53-55,共3页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2016KYB317)
关键词
辅助生殖技术
新生儿期疾病
神经发育
预后影响因素
Assisted reproductive technology(ART)
Neonatal disease
Neurodevelopment
Prognosis influencing factor
