摘要
息肉状脉络膜血管病变(PCV)是一种特殊的眼底疾病,以异常脉络膜血管的息肉状病灶为特征,伴或不伴异常分支血管网及玻璃膜疣。PCV在有色人种中的发病率比较高,特别是亚洲人和黑人,是这些人群中主要的新生血管性黄斑疾病。吲哚菁绿血管造影(ICGA)可以清楚发现PCV中的异常脉络膜血管,对诊断PCV至关重要。将PCV从其他更典型的异常脉络膜血管增生性疾病中分辨出来的临床特征包括:反复发生的视网膜下出血、血液性视网膜色素上皮层脱离(PED)、视网膜下渗出和浆液性视网膜脱离。对有症状的PCV患者治疗是因为其会引起潜在、不可逆转的视力丢失,治疗方法有多种,主要有:激光光凝、光动力疗法(PDT)、抗血管内皮生长因子(VEGF)治疗,以及PDT联合抗VEGF治疗。本文主要对PCV治疗方法的进展进行回顾。
Polypoidal choroidal vasculopathy(PCV)is a peculiar retina disorder involving the abnormal choroidal vasculature characterized by the presence of aneurysmal polypoidal lesions(polyps)with or without branching vascular network(BVN)and concomitant drusen.PCV is more prevalent among pigmented races,especially Asians and Blacks and the principal vascular composition of them experiencing neovascular maculopathies.Indocyanine green angiography(ICGA)is particularly reliable in detecting these choroidal abnormalities seen in PCV and essential for a definitive diagnosis of PCV.Specific clinical features that distinguish PCV from more typical proliferations of abnormal choroidal vessels include recurrent subretinal hemorrhage;serosanguineous pigment epithelial detachment(PED),subretinal exudation and serous retinal detachment.Treatment in patients with symptomatic PCV due to potentially irreversible visual loss.The principle therapies are laser photocoagulation,photodynamic therapy(PDT),Anti-vascular Endothelial Growth Factor(anti-VEGF),and combinations of PDT and anti-VEGF therapy.The main purpose of the review is aim to provide updates on the therapeutic options for PCV.
作者
凌啟鹏
韩冬梅
吴星伟
Ling Qipeng;Han Dongmei;Wu Xingwei(Nanjing Medical University,Nanjing 210029;Chenguang Eye)
出处
《临床眼科杂志》
2018年第3期281-284,共4页
Journal of Clinical Ophthalmology
关键词
息肉状脉络膜血管病变
治疗
Polypoidal choroidal vasculopathy
Therapeutic approaches
