摘要
目的探讨同型半胱氨酸(HCY)及血脂七项指标在心脑血管疾病预防治疗中的应用。方法健康对照组200例,脑卒中患者组1,525例,冠心病患者组326例,用相同的方法检测其血清中的HCY及血脂七项指标,并进行比较分析。结果心脑血管疾病患者中HHCY与非HHCY两组比较TC、TG、LDL-C、APOB、Lp(a)水平无明显差异(P>0.05),与HDL-C及APOAI比较有显著差异(P<0.01)。脑卒中患者和冠心病患者HCY及血脂七项指标与对照组比较,TC的比较参数分别为t=-0.312,P=0.755和t=-0.833,P=0.405,无显著差异。其余指标与对照组比较有显著差异(P<0.01)。结论 HCY是造成动脉粥样硬化和心脑血管疾病发生的独立危险因素;HCY与血脂同时检测,对心脑血管疾病的预防和治疗具有重要意义。
Objective To investigate the application of homocysteine(HCY)and seven indicators of blood lipids in the prevention and treatment of cardiovascular and cerebrovascular diseases.Methods Among 200 cases of healthy control group,1,525 cases of stroke patients and 326 cases of coronary heart disease group,the same method was employed to delect the HCY and blood lipid indicators in serum and conduct comparative analysis.Results There was no significant difference between HHCY and non-HHCY in patients with cardiovascular and cerebrovascular diseases in terms of TC,TG,LDL-C,APOB,and Lp(a)(P>0.05).While with regard to HDL-C and APOAI,obvious difference could be seen(P<0.01).Comparing HCY and blood lipid indicators between patients of stroke as well as coronary heart disease,and patients of the control group,it was found that the comparison parameters of TC were t=-0.312,P=0.755 and t=-0.833,P=0.405,showing no significant difference.But the other indexes were significantly different from the control group(P<0.01).Conclusion HCY is an independent risk factor causing atherosclerosis and cardiovascular and cerebrovascular disease;simultaneous detection of HCY and blood lipids,is of great value for the prevention and treatment of cardiovascular and cerebrovascular diseases.
作者
王宏伟
吕雪霞
胡吉东
Hongwei WANG;Xuexia LV;Jidong HU(Department of Clinical Laboratory,Jishan People's Hospital,Jishan 043200,China)
出处
《临床检验杂志（电子版）》
2018年第3期521-523,共3页
Clinical Laboratory Journal(Electronic Edition)
关键词
脑卒中
冠心病
同型半胱氨酸
血脂七项
Cerebral apoplexy
Coronary heart disease
Homocysteine
Seven items of blood lipid
