摘要
目的研究女性系统性红斑狼疮(SLE)患者血清中免疫球蛋白、补体的水平及其与自身抗体的相关性。方法女性SLE患者82例,71例非SLE疾病对照组患者,同时选择同期健康体检者67例,分别对其血清中的免疫球蛋白IgG、补体C3和C4水平及自身抗体的表达情况进行检测分析。结果 SLE组和非SLE疾病对照组与正常对照组比较,各指标阳性率差异有统计学意义(P<0.01)。SLE组中ACA、U1-nRNP、抗Sm抗体、抗ds DNA抗体、Nucleosome、Histone、ARPA的阳性率均高于非SLE疾病对照组,差异有统计学意义(P<0.05)。女性SLE组血清IgG水平高于健康对照组(P<0.05),补体C4水平低于健康对照组(P<0.05),补体C3水平显著低于健康对照组(P<0.01),抗Sm抗体阳性的女性SLE患者血清C3、C4水平均低于抗Sm抗体阴性的女性SLE患者。抗Sm、U1-nRNP、抗ds-DNA、Nucleosome、Histone、ARPA联合诊断SLE敏感性为63.4%,明显高于单一检测抗Sm抗体,差异有统计学意义(P<0.01)。结论抗心磷脂抗体、IgG、C3、C4及自身抗体在女性SLE患者与健康对照者中存在明显差异,多种抗体联合检测能够提高对SLE的诊断率,对系统性红斑狼疮患者的早期诊断、治疗及预后判断等均具有重要临床意义。
Objective To investigate the serum levels of immunoglobulin and complement in female patients with systemic lupus erythematosus(SLE),and to explore the correlation between the serum levels of immunoglobulin,complement and autoantibodies.Methods A total of 82 female patients with SLE who were treated in our hospital from March 2015 to March 2017 were enrolled as SLE group,and 71 patients with non SLE diseases were enrolled as non SLE group,at the same time,the other 67 healthy subjects were enrolled as control group.The serum levels of immunoglobulin IgG,complement C3,C4 and autoantibody were detected and compared among the three groups.Results There were significant differences in the positive rates of different indexes between SLE group,non SLE group and control group(P<0.01).The positive rates of ACA,U1-nRNP,anti-Sm antibody,anti-dsDNA antibody,nucleosome,histone and ARPA in SLE group were significantly higher than those in control group(P<0.05).Moreover the serum levels of IgG in SLE group were significantly higher than those in control group(P<0.05),however,the levels of complement C3,C4 were significantly lower than those in control group(P<0.05).in addition the serum levels of C3 and C4 in patients with positive anti-Sm antibody were significantly lower than those of patients with gegative anti-Sm antibody.Besides the sensitivity of combination detection of anti-Sm,U1-nRNP,anti-ds-DNA,nucleosome,histone and ARPA in diagnosis of SLE was 63.4%,which was significantly higher than that of simple detection of anti-Sm antibody(P<0.01).Conclusion There are significant differences in anticardiolipin antibodies,IgG,C3,C4 and autoantibodies between female patients with SLE and healthy subjects.The combination detection of multiple antibodies can increase the diagnostic rate of SLE,which has important clinical significance in early diagnosis and treatment as well as prognosis evaluation for the patients with SLE.
作者
张红
刘兆玮
李森
种肖宇
ZHANG Hong;LIU Zhaowei;LI Sen(Department of Clinical Laboratory,Harrison International Peace Hospital,Hebei,Hengshui 053000,China)
出处
《河北医药》
CAS
2018年第14期2166-2170,共5页
Hebei Medical Journal
