摘要
目的:分析索拉唑联合阿莫西林治疗幽门螺杆菌(Hp)相关的十二指肠溃疡(DU)患者的疗效及安全性。方法:选取2016年4月至2017年1月河南省太康县第二人民医院治疗Hp相关的DU患者98例,随机数字表法分为两组,各49例。对照组予以奥美拉唑+阿莫西林治疗,观察组予以兰索拉唑+阿莫西林治疗。用药4周后,统计对比两组临床治疗效果、Hp清除率及不良反应发生率,且治疗后随访6个月,对比两组复发情况。结果:观察组治疗有效率为93.88%(46/49),较对照组77.55%(38/49)高,差异有统计学意义(P<0.05);用药后4周,观察组Hp清除率85.71%(42/49)高于对照组67.35%(33/49),差异具有统计学意义(P<0.05);观察组不良反应发生率6.12%(3/49)与对照组12.24%(6/49)相比,差异无统计学意义(P>0.05);治疗后随访6个月,观察组复发率6.12%(3/49)较对照组24.49%(12/49)低,差异有统计学意义(P<0.05)。结论:兰索拉唑联合阿莫西林治疗Hp相关的十二指肠溃疡临床疗效较好,可提高Hp清除率,并减少复发情况,具有较高安全性。
Objective:To investigate the efficacy and safety of lansoprazole and amoxicillin in the treatment of Helicobacter pylori(Hp)-associated duodenal ulcer(DU)patients.Methods:From April 2016 to January 2017,98 cases of Hp-related DU patients treated by our hospital were randomly divided into two groups,49 cases in each.The control group was treated with omeprazole+amoxicillin,the observation group was treated with lansoprazole+amoxicillin.After 4 weeks of medication,the clinical treatment effect,the Hp clearance rate and the incidence of adverse reactions were compared between the two groups.After 6 months of follow-up,the recurrence of the two groups was compared.Results:The effective rate of treatment in the observation group was 93.88%(46/49),which was higher than that of the control group 77.55%(38/49),and the difference was statistically significant(P<0.05).Four weeks after treatment,the Hp clearance rate in the observation group was 85.71%(42/49),which was higher than that in the control group(67.35%,33/49),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 6.12%(3/49);compared with 12.24%(6/49)in the control group,there were insignificant differences(P>0.05).After treatment for 6 months,the recurrence rate in the observation group was 6.12%(3/49),which was lower than that in the control group[24.49%(12/49)],and the difference was statistically significant(P<0.05).Conclusion:Lansoprazole combined with amoxicillin in the treatment of Hp-associated duodenal ulcer patients is effective.It can improve the clearance rate of Hp,and reduce the recurrence.Besides,it has high security.
作者
吴玉强
陆晓
WU Yu-qiang;LU Xiao(Department of Internal Medicine,The Second People's Hospital of Taikang County,Zhoukou Henan 461400,China;Department of Digestive Internal Medicine,Henan Anyang Tumor Hospital,Anyan Henan 455000,China)
出处
《药品评价》
CAS
2018年第11期62-64,共3页
Drug Evaluation
关键词
兰索拉唑
十二指肠溃疡
阿莫西林
幽门螺杆菌
Lansoprazole
Duodenal Ulcer
Amoxicillin
Amoxicillin
Helicobacter Pylori
