摘要
目的探讨丁螺环酮联合氟西汀治疗抑郁症的临床疗效。方法选取本院2014年1月至2017年6月符合ICD-10抑郁症诊断标准的186例抑郁症患者,按不同治疗方案随机分成对照组和观察组2组:对照组为氟西汀+安慰剂组(n=93),观察组为氟西汀+丁螺环酮组(n=93),疗程8w。通过Hamilton抑郁量表(HAMD-17项)和不良反应症状量表(TESS)观察治疗前、及治疗后2、4、6、8w 2组患者的临床治疗效果与不良反应。结果 2组患者在治疗前和治疗2w后的HAMD-17项评分相比差异无统计学意义(P>0.05),然而从第4周开始,2组HAMD-17项评分相比差异有统计学意义(P<0.05)。观察组患者痊愈率(30.11%vs 16.13%,χ~2=5.112,P=0.024)和总有效率(88.17%vs 73.12%,χ~2=6.751,P=0.009)均显著高于对照组患者。从第4周开始,2组患者TESS评分相比(P<0.05)。观察组患者与对照组相比失眠发生率显著降低(12.90%vs 24.73%,χ~2=4.258,P=0.039)。结论丁螺环酮可增强氟西汀治疗抑郁症的疗效,同时对改善抑郁症睡眠障碍有显著作用。
Objective To investigate the effect of buspirone combined with fluoxetine on the treatment of depression.Method A total of 186 treatment free patients with depression meeting ICD-10 diagnostic criteria were recruited from January 2014 to June 2017.Patients were randomly divided into control group(n=93)and observation group(n=93),patients from control group were treatment with fluoxetine and placebo,and those from observation group were treatment with fluoxetine and buspirone.The treatments lasted eight weeks.The 17-item Hamilton Rating Scale(HAMD-17)and Treatment Emergent Symptom Scale(TESS)were applied to assess the therapeutic effect and adverse reactions before and after 2,4,6,8 weeks of treatment.Results The scores of HAMD-17 were no significant statistical differences before and the first 2 weeks after treatment,however,they were significant statistical differences from 4 weeks to 8 weeks after treatment between the two groups.The recovery ratios and total effective rate of observation group were dramatically higher than those in the controls(30.11%vs 16.13%,χ2=5.112,P=0.024)(88.17%vs 73.12%,χ2=6.751,P=0.009).From the fourth weeks after the treatment,there was significant statistical differences in the score of TESS between the two groups.The incidence rate of insomnia in the observation group was more than that in the control group(12.90%vs 24.73%,χ2=4.258,P=0.039).Conclusion The effect of fluoxetine on the treatment of depression can be enhanced by the treatment of buspirone,and buspirone combined with fluoxetine significantly improved the sleep disorder of depression.
作者
白轩
孙宏利
卜岚
刘晓凤
杨璐
李超
Bai Xuan;Sun Hongli;Bo Lan;Liu Xiaofeng;Yang Lu;Li Chao(Department of Second Clinical Psychology,the Xian Mental Health Center,Shanxi 710061,China)
出处
《脑与神经疾病杂志》
2018年第5期265-268,共4页
Journal of Brain and Nervous Diseases
基金
国家自然科学基金资助课题(81701331)
