摘要
多囊卵巢综合征(PCOS)是常见于育龄期妇女的生殖内分泌疾病,其发病机制与高雄激素血症与胰岛素抵抗相互作用、下丘脑-垂体-卵巢轴功能异常、垂体-肾上腺轴功能及中枢胰岛素受体作用异常等有关。胰高血糖素素样肽1受体激动剂(GLP-1Ra)除改善胰岛素抵抗、减轻体质量外,还调节改善高雄激素等性激素和促性腺激素水平;减轻PCOS的慢性炎症、改善糖脂代谢紊乱及生殖功能;GLP-1Ra为PCOS的治疗提供了新的治疗手段,在PCOS的病理生理作用及临床价值有待进一步研究。
Polycystic ovary syndrome(PCOS)is a heterogeneous gynecologic disease which commonly affects women of reproductive ages.Altered interaction between hyperandrogenemia and insulin resistance,impaired function of hypothalamic-pituitary-ovarian axis and pituitary-adrenal axis,malfunction of central insulin receptors are factors involved.Apart from its actions on improving insulin resistance and weight control,glucagon-like peptide-1 receptor agonist(GLP-1Ra)can also modulate hyperandrogenemia,gonadotropin levels,relieve inflammation,improve carbohydrate lipid metabolism and reproductive functions of PCOS patients.GLP-1Ra offers a new treatment option for PCOS patients.The role of GLP-1Ra in PCOS pathophysiology and its clinical value for PCOS patients need further investigation.
作者
郑灿滨
林少达
杨晓平
ZHENG Canbin;LIN Shaoda;YANG Xiaoping(Department of Endocrinology,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China)
出处
《医学综述》
2018年第8期1600-1605,共6页
Medical Recapitulate
关键词
胰升糖素样肽1
受体激动剂
多囊卵巢综合征
胰岛素抵抗
Glucagon-like peptide-1
0x09Receptor agonist
0x09Polycystic ovary syndrome
Insulin resistance
