摘要
目的探讨C反应蛋白(C-reactive protein,CRP)在老年脑梗死检测中的应用价值。方法回顾性分析该院2014年8月—2017年9月收治的脑梗死老年患者78例,设为鉴别组,另选择同期来院体检的健康人78名,设为参照组;并根据NIHSS评分将脑梗死患者分为轻度、中度、重度3个亚组,根据梗死体积将脑梗死患者分为小梗死病灶、中梗死病灶、大梗死病灶3个亚组,观察对比各组患者CRP水平。结果鉴别组CRP水平(16.75±2.25)mg/L高于参照组(2.30±0.70)mg/L(t=54.159,P<0.05)。重型组CRP水平(17.03±1.97)mg/L高于轻型组(11.54±1.46)mg/L和中型组(14.75±1.25)mg/L(t=4.430,10.976,P<0.05),且中型组CRP水平(14.75±1.25)mg/L高于轻型组(11.54±1.46)mg/L,(t=9.063,P<0.05)。大梗死病灶患者CRP水平(15.98±2.02)mg/L高于中梗死病灶(9.50±2.35)mg/L和小梗死病灶(9.13±2.07)mg/L(t=8.005,9.768,P<0.05);中梗死病灶CRP水平(9.50±2.35)mg/L与小梗死病灶(9.13±2.07)mg/L相比差异无统计学意义(t=0.679,P>0.05)。结论血清CRP水平与脑梗死存在明显关联,CRP水平升高可作为判断脑梗死病情严重程度的独立危险因子,对老年脑梗死患者早期诊断、病情程度和预后判定有重要的参考价值。
Objective This paper tries to investigate the value of C-reactive protein (CRP) in the detection of senile cere-l)ral infarction. Methods A retrospective analysis of 78 elderly patients with cerebral infarction admitted from August 2014 to September 2017 in this hospital was performed as the identifioation group. Another 78 healthy subjects who were hospitalized during the same period were selected as the reference group. According to the NIHSS score, the patients with cerebral infarction were divided into mild, moderate and severe subgroups. According to infarct volume, the patients with cere-bral infarction were divided into three subgroups: small infarction lesion, middle infarct lesion and large infarct lesion. The levels of CRP in each group were compared. Results The CRP level of the discriminant group (16.75±2.25) mg/L was higher than that of the reference group (2.30±0.70) mg/L,(t=54.159, fkO.OS). The level of CRP in severe group (17.03± 1.97) mg/L was significantly higher than that in mild group (11.54± 1.46) mg/L and middle group (14.75 ± 1.25) mg/L, 4.430, 10.976), and that in the middle group was(14.75±1.25) mg/L higher than the light group(11.54±1.46) mg/L,(f=9.063, ^<0.05). The CRP level of patients with large infarction (15.98±2.02)mg^L was higher than that of middle infarction (9.50± 2.35) m#L and small infarclion(9.13±2.07) mg/L,(f= 8.005,9.There was no significant difference in CRP level between infarcted lesions (9.50±2.35) mg/L and small infarct size (9.13 ± 2.07) mg/L(i= 0.679, P>0.05). Conclusion There is a significant correlation between serum CRP level and cerebral infarction. CRP level may be used as an independent risk factor for judging the severity of cerebral infarction. It has important reference value for the early diagnosis, severity and prognosis of elderly patients with cerebral infarction.
作者
郭贤莎
胡友明
张新卫
陈汉东
GUO Xian-sha;HU You-ming;ZHANG Xin-wei;CHEN Han-dong(Department of Laboratory,Shashi People’s Hospital,Jingzhou,Hubei Province,434000 China)
出处
《中外医疗》
2018年第7期179-181,共3页
China & Foreign Medical Treatment
关键词
C反应蛋白
老年脑梗死
诊断价值
C-reactive protein
Cerebral infarction
Diagnostic value