摘要
他汀类药物为3-羟基-3-甲基戊二酰辅酶A(HMG-Co A)还原酶抑制剂,通常用于治疗高脂血症,预防心血管事件的发生。最近一些研究表明他汀类药物还可降低结直肠癌发生风险,但对其化学预防作用仍存在争议。本文通过总结国内外相关研究,对他汀类药物对结直肠癌和结直肠腺瘤的预防作用及其作用机制作一概述。
Statins,the inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase,are mostly prescribed for the treatment of hyperlipidemia and prevention of cardiovascular events.Several studies have suggested that statins can reduce the risk of colorectal cancer,however,there is still a debate on its chemopreventive effect.This article summarized the local and overseas studies focusing on this issue,and made a brief overview on the effect of statins in prevention of colorectal cancer and adenoma and its potential mechanisms.
作者
钱为芬
徐萍萍
韩真
QIAN Weifen;XU Pingping;HAN Zhen(Department of Gastroenterology,Yiji Shan Hospital,the First Affiliated Hospital of Wannan Medical College,Wuhu,Anhui Province(241001))
出处
《胃肠病学》
2018年第4期245-247,共3页
Chinese Journal of Gastroenterology
基金
皖南医学院重点科研项目培育基金项目(WK2017ZF06)
关键词
他汀类药物
结直肠肿瘤
腺癌
腺瘤
化学预防
Statins
Colorectal Neoplasms
Adenocarcinoma
Adenoma
Chemoprevention
