摘要
目的研究2型糖尿病合并非酒精性脂肪肝患者炎性因子、氧化应激、硫氧还蛋白互作蛋白(TXNIP)水平,并探讨其相关性。方法 102例非酒精性脂肪肝患者分为血糖正常组(空腹血糖<6.1 mmol/L,餐后2 h血糖<7.8 mmol/L)、糖耐量异常组(空腹血糖6.1~6.9 mmol/L,或餐后2 h血糖7.8~11.0 mmol/L)、2型糖尿病组(空腹血糖≥7.0 mmol/L,餐后2 h血糖≥11.1 mmol/L)。观察3组患者炎性因子[C-反应蛋白(CRP)、白介素(IL)-1β、IL-6、肿瘤坏死因子-α(TNF-α)、脂联素]、氧化应激[还原型谷胱甘肽(GSH)、超氧化物歧化酶T-SOD、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)]、TXNIP水平,并对其进行相关性分析。结果糖耐量异常组和2型糖尿病组CRP、IL-6、TNF-α水平均高于血糖正常组,脂联素水平低于血糖正常组,差异均有统计学意义(P<0.05)。2型糖尿病组CRP、IL-1β、IL-6、TNF-α水平均高于血糖正常组和糖耐量异常组,脂联素水平低于血糖正常组和糖耐量异常组,差异均有统计学意义(P<0.05)。糖耐量异常组IL-1β水平与血糖正常组比较,差异无统计学意义(P>0.05)。糖耐量异常组、2型糖尿病组GSH水平高于血糖正常组,T-SOD、GSH-Px、CAT水平低于血糖正常组,差异均有统计学意义(P<0.05)。2型糖尿病组T-SOD、GSH-Px、CAT水平低于糖耐量异常组,差异均有统计学意义(P<0.05),2组GSH水平比较,差异无统计学意义(P<0.05)。糖耐量异常组、2型糖尿病组TXNIP水平高于血糖正常组,2型糖尿病组TXNIP水平高于糖耐量异常组,差异均有统计学意义(P<0.05)。Pearson相关性分析表明,TXNIP水平与CRP、IL-6、TNF-α、GSH水平呈正相关,与脂联素、T-SOD、GSH-Px和CAT呈负相关(P<0.05)。以TXNIP为应变量,CRP、IL-6、TNF-α、GSH、脂联素、T-SOD、GSH-Px和CAT为自变量进行多重线性逐步回归分析,结果显示,在排除多种因素相互影响后,TXNIP与CRP、IL-6和TNF-α呈正相关(P<0.05)。结论合并非酒精�
Objective To investigate the levels of inflammatory factors,oxidative stress and thioredoxin interacting protein(TXNIP)in patients with type 2 diabetes mellitus complicated by non alcoholic fatty liver,and to explore their correlation.Methods A total of 102 patients with non-alcoholic fatty liver were divided into normal blood glucose group(fasting blood glucose<6.1 mmol/L,and postprandial blood glucose<7.8mmol/L),abnormal glucose tolerance group(fasting blood glucose 6.1~6.9mmol/L,or 2h postprandial blood glucose 7.8~11.0mmol/L),type 2 diabetes group(fasting blood glucose≥7.0mmol/L,and 2h postprandial blood glucose≥11.1mmol/L).The levels of inflammatory cytokines including C reaction protein(CRP),interleukin 1β(IL-1β),interleukin 6(IL-6),tumor necrosis factorα(TNF-α),and adiponectin and oxidative stress indexes including reduced glutathione(GSH),superoxide dismutase(T-SOD),glutathione peroxidase(GSH-Px),catalase(CAT)as well as TXNIP levels were observed and compared among the three groups.Results The levels of CRP,IL 1β,IL-6 and TNF-αin abnormal glucose tolerance group and type 2 diabetes group were significantly higher than those in normal blood glucose group,however,the adiponectin levels were significantly lower than those in normal blood glucose group(P<0.05).The levels of CRP,IL-1β,IL-6 and TNF-αin type 2diabetes group were significantly higher than those in normal blood glucose group and abnormal glucose olerance group,but adiponectin levels were significantly lower than those in normal glucose group and abnormal glucose tolerancegroup(P<0.05).There were no and CAT were significantly lower than those in normal blood glucose group(P<0.05).The levels of T-SOD,GSH-Px and CAT in type 2 diabetes group were significantly lower than those in abnormal glucose tolerance group(P<0.05),but there were no significant differences in GSH levels between the two groups(P>0.05).In addition the TXNIP levels in abnormal glucose tolerance group and type 2 diabetes mellitus group were significantly higher than those
作者
谈力欣
刘焱
张秀云
焦骞
檀力静
TAN Lixin;LIU Yan;ZHANG Xiuyun(Department of Diabetes and Rehabilitation,South Branch,The Second Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050000,China)
出处
《河北医药》
CAS
2018年第9期1285-1289,共5页
Hebei Medical Journal
基金
河北省医学科学研究重点计划课题(编号:20150153)
关键词
糖尿病
2型
脂肪肝
非酒精性
炎性因子
氧化应激
硫氧还蛋白互作蛋白
diabetes mellitus,type 2
fatty liver,non-alcoholic
inflammatory factors
oxidative stress
thioredoxin interacting protein
