摘要
目的探究自愿终止妊娠的8~13周孕妇在不同给药间隔使用米非司酮配伍米索前列醇后的效果。方法研究对象为2015年6月~2016年6月收入的自愿终止妊娠的8~13周孕妇,用随机排列表法分为观察组与对照组,40例观察组顿服200mg米非司酮后,每1小时阴道给予0.6mg米索前列醇,另40例对照组顿服200mg米非司酮后,每12小时阴道给予0.6mg米索前列醇。比较两组病人实施不同治疗对胚胎排出时间、出血量、月经复潮、不良反应的影响。结果观察组流产成功率(85.00%)显著比对照组(95.00%)低(χ2=5.556,P<0.05);观察组在首次用米非司酮至胚胎排出时间上显著比对照组少(t=-26.408,P<0.05);在首次用米索前列醇至胚胎排出时间上显著比对照组高(t=14.366,P<0.05);在流产后出血时间、流产后出血量、月经复潮上观察组与对照组比较差异无统计学意义(t=0.205、-0.828,P>0.05);且不良反应发生率(35.00%)比对照组(50.00%)低(χ2=4.604,P<0.05)。结论在米非司酮配伍米索前列醇对自愿终止妊娠的8~13周孕妇进行药物流产时,采用不同时间给药对流产成功率及并发症发生率均有影响,虽然1h间隔给药不良反应发生率较低,但发生的不良反应均为轻度不良反应,临床治疗难度较小,且流产成功率不如12h间隔给药,故当准备药物给药时应选择12h间隔给药,流产成功率较高。
Objective To investigate the effect of mifepristone combined with misoprostol in 8-13 weeks of voluntary termination of pregnancy in different dosing intervals.Methods The subjects were 8-13 weeks pregnant women who voluntarily terminated their pregnancy from June 2015 to June 2016.They were randomly divided into observation group and control group.40 cases in the observation group were given 200mg mifepristone,and 0.6mg misoprostol was given to the vagina per 1h.The other 40 patients in the control group were given 200mg mifepristone,and 0.6mg misoprostol was given to the vagina per 12h.The effects of different treatments on embryo expulsion time,bleeding volume,menstrual recovery and adverse reactions were compared between the two groups.Results The success rate of abortion in the observation group(85.00%)was significantly lower than that in the control group(95.00%)(χ2=5.556,P<0.05).The time of first use of mifepristone to embryo in the observation group was significantly less than that in the control group(t=-26.408,P<0.05).The time of first misoprostol to embryo was significantly higher than that of the control group(t=14.366,P<0.05).There was no significant difference between the observation group and the control group in the time of bleeding after abortion,the amount of bleeding after abortion,and the menstrual cycle(t=0.205,-0.828,P>0.05).The incidence of adverse reactions(35.00%)was lower than that of the control group(50.00%)(χ2=4.604,P<0.05).Conclusion When mifepristone combined with misoprostol was used for drug abortion in 8-13 weeks of of voluntary termination of pregnancy,the use of different time administration have an effect on the success rate of abortion and the incidence of complications.Although the incidence of adverse reactions in 1h interval is low,the adverse reactions are mild adverse reactions.The difficulty of clinical treatment is small,and the success rate of abortion is not as good as that of 12h interval.Therefore,when preparing drugs,12h interval should be chosen,and the success
作者
余碧雅
YU Biya(Huidong County People's Hospital of Guangdong Province,Huidong 516300,China)
出处
《中国医药科学》
2018年第7期108-110,共3页
China Medicine And Pharmacy
关键词
米非司酮
米索前列醇
给药间隔
终止妊娠
流产效果
Mifepristone
Misoprostol
Dosing intervals
Termination of pregnancy
Abortion effect
