摘要
目的探讨配对盒基因8(PAX-8)蛋白在宫颈腺上皮病变鉴别诊断中的作用。方法收集25例良性宫颈腺上皮(BEG)、14例原位宫颈腺癌(AIS)、19例浸润性宫颈腺癌(ECA)和20例子宫内膜样腺癌(UEC)活检或手术标本,应用免疫组织化学染色检测各组织中PAX-8蛋白的表达情况。结果 PAX-8蛋白在BEG中呈弥漫性的强阳性核表达,在AIS和浸润性ECA中呈斑片或局灶性的弱阳性核表达。PAX-8蛋白在BEG、AIS、浸润性ECA组织中的阳性表达率分别为100%(25/25)、92.8%(13/14)、73.7%(14/19),其中BEG的PAX-8蛋白阳性表达率高于浸润性ECA,而BEG与AIS、AIS与浸润性ECA的PAX-8蛋白阳性表达率比较,差异均无统计学意义(均P>0.05)。PAX-8蛋白在UEC组织中的阳性表达率为100.0%(20/20),高于浸润性ECA(P<0.05)。结论 PAX-8在宫颈腺上皮良性与恶性病变以及浸润性ECA与UEC的鉴别诊断中具有一定的作用。
Objective To explore the role of paired box gene 8(PAX-8)protein in the differential diagnosis of cervical glandular epithelial lesions.Methods The biopsy or surgical specimens of 25 cases of benign endocervical glandular epithelium(BEG),14 cases of cervical adenocarcinoma in situ(AIS),19 cases of invasive endocervical adenocarcinoma(ECA)and 20 cases of uterine endometrioid carcinoma(UEC)were collected.Immunohistochemistry was used to detect the PAX-8 protein expression in each tissues.Results Diffuse and strongly positive expression of PAX-8 protein was observed in the nucleus of BEG tissues,patchy/local and weekly positive expression of PAX-8 protein was observed in the nucleus of AIS and invasive ECA tissues.The positive expression rates of PAX-8 protein in BEG,AIS and invasive ECA tissues were 100%(25/25),92.8%(13/14)and 73.7%(14/19)respectively.the positive expression rate of PAX-8 protein in BEG tissues was higher than that in invasive ECA tissues,and no significant difference was found in the positive rate of PAX-8 protein between BEG and AIS tissues,or between AIS and invasive ECA tissues(all P>0.05).The positive expression rate of PAX-8 protein in UEC tissues was 100.0%(20/20),and was higher than that in invasive ECA tissues(P<0.05).Conclusion
作者
莫洪敏
于江
罗迎春
刘小芬
张海鹏
齐旻芳
黄高翔
MO Hong-min;YU Jiang;LUO Ying-chun;LIU Xiao-fen;ZHANG Hai-peng;QI Min-fang;HUANG Gao-xiang(Department of Gynaecology,Obstetrics and Pediatrics No.181 Hospital of the Chinese People′s Liberation Army,Guilin 541002,China;Department of Pathology,No.181 Hospital of the Chinese People′s Liberation Army,Guilin 541002,China)
出处
《广西医学》
CAS
2018年第7期750-752,共3页
Guangxi Medical Journal
基金
广西桂林市科学研究与技术开发计划(2016012702-3)
关键词
宫颈腺上皮病变
配对盒基因8蛋白
鉴别诊断
Cervical glandular epithelial lesion
Paired box gene 8 protein
Differential diagnosis
