摘要
MLLT6又称为AF17(ALL1 fused gene from chromosome 17 protein),位于人类17号染色体长臂2区1带(17q21),最初在白血病中作为MLL的伙伴基因被分离出来。有文献报道MLLT6在人体内具有维持血压稳定的功能。同时MLLT6作为癌基因或和混合谱系白血病(Mixed lineage leukemia,MLL)的基因融合(t(11;17)(q23;q21)等)协同促进急性骨髓性白血病(AML)的发生发展。本文就MLLT6及MLL-MLLT6融合蛋白在白血病中的研究进展进行全面概述。
MLLT6(Myeloid/Lymphoid or mixed-lineage leukemia(Trilhorax homolog,Drosophila);Translocated to,6)’also known as AF17(ALL1 fused gene from chromosome 17 protein)and located in chromosome 17 long arm 2 zone 1 band(17q21),was originally isolated as a MLL partner gene in leukemia.It has been reported that MLLT6 has the function of maintaining blood pressure stability.MLLT6 synergistically promotes the development of acute myeloid leukemia(AML)as an oncogene or a gene fusion with mixed lineage leukem ia(t(11;1 7)(q 2 3;q21)).This article provides a comprehensive overview of the research progress of MLLT6 and MLL-MLLT6 fusion protein in leukemia.
作者
李毅鹏
张鑫宇
吕涵柠
孙立春
LI Yipeng;ZHANG Xinyu;LV Hanning;SUN Lichun(Harbin Medical University Cancer Hospital,Harbin 150081,China)
出处
《实用肿瘤学杂志》
CAS
2018年第2期135-139,共5页
Practical Oncology Journal
基金
黑龙江省自然科学基金面上项目(编号:H201447)
