摘要
目的探讨右美托咪定不同给药方式对膝关节炎行全膝关节置换术的临床价值。方法回顾性分析2015年1月—2016年1月雅安市中医医院收治的膝关节炎行全膝关节置换的184例的临床资料,根据给药方式分为A组94例和B组90例,A组予以静脉泵注右美托咪定,B组予以肌内注射右美托咪定,比较2组术后情况、炎性因子水平及不良反应。结果 A组术后第1次使用镇痛泵时间较B组延长,术后24 h舒芬太尼用量较B组减少,术后疼痛较B组减轻,炎性因子水平低于B组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论右美托咪定静脉给药对膝关节置换术患者术后镇痛时间更长,且更大程度减轻术后炎性反应。
Objective To investigate clinical value of different modes of Dexmedetomidine on analgesic effect and inflammatory reaction after total knee arthroplasty in patients with gonarthritis.Methods Clinical data of 184 patients with knee osteoarthritis undergoing total knee arthroplasty during January 2015 and January 2016 was retrospectively analyzed,and the patients were divided into group A(n=94)and group B(n=90)according to administration methods.Group A was treated with Dexmedetomidine by venous pump,while group B was treated with Dexmedetomidine by intramuscular injection.Postoperative conditions,inflammatory factors and incidence rate of adverse reactions were compared in two groups.Results In group A,time of the first use of analgesia pump after operation was longer,and Sufentanil dosage within postoperative 24 h was less,and postoperative pain was less,and levels of inflammatory factors were lower than those in group B(P<0.05).There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).Conclusion Dexmedetomidine by intravenous application may achieve longer duration of postoperative analgesia and less postoperative inflammatory response in patients undergoing knee arthroplasty.
作者
何桃
陈洪文
杨毅
秦志均
HE Tao;CHEN Hong-wen;YANG Yi;QIN Zhi-jun(Department of Anesthesiology,Ya'an Hospital of Traditional Chinese Medicine,Ya'an,Sichuan 625000,China)
出处
《解放军医药杂志》
CAS
2018年第4期96-99,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
四川省卫生厅科研课题(140109)
