摘要
目的探讨白细胞介素(IL)-17A启动子基因多态性与冠心病患者血脂和炎症因子的关联。方法收集2013年4月至2016年12月在该院入院治疗且确诊的冠心病患者241例为冠心病组,另取该院同期常规健康体检者68例为对照组。检测IL-17A基因启动子rs8193036基因型、血脂和炎症因子。结果与对照组相比,冠心病组IL-17A启动子rs8193036位点基因型CC、CT、TT分布差异有统计学意义(P<0.05),冠心病组C等位基因频率显著高于对照组(P<0.05)。与冠心病组CT+TT基因型比较,冠心病组CC基因型的三酰甘油、IL-17A、IL-6、IL-8和肿瘤坏死因子-α水平显著升高(P<0.05),高密度脂蛋白胆固醇水平显著降低(P<0.05),血清总胆固醇和低密度脂蛋白胆固醇水平差异无统计学意义(P>0.05)。结论 IL-17A基因启动子rs8193036多态性与冠心病的发病有相关性,其中C等位基因是冠心病重要的遗传标记,IL-17A基因启动子rs8193036多态性可能通过影响血脂及炎症因子水平而参与冠心病的发生。
Objective To investigate the association between interleukin-17 A(IL-17 A)gene promoter polymorphism and blood lipid and inflammatory factors in coronary heart disease.Methods A total of 241 patients with coronary heart disease who were admitted to hospital from April 2010 to December 2016 were enrolled in this study.68 cases of healthy subjects were collected.IL-17 gene promoter rs8193036 genotype,blood lipid and inflammatory factors were detected and compared.Results Compared with the control group,the genotype CC,CT and TT of the rs8193036 genotype in the coronary heart disease group were significantly different(P<0.05),and the frequency of C allele in the coronary heart disease group was significantly higher than that in the control group(P<0.05).The levels of triglyceride,low-density lipoproteincholesterol,high density lipoprotein cholesterol,interleukin-17a,interleukin-6,interleukin-8 and tumor necrosis factor alpha in CC genotype of tumor necrosis factor alpha group were significantly higher than those in tumor necrosis factor alpha group(P<0.05),high density lipoprotein cholesterol decreased significantly(P<0.05).Total cholesterol and low-density lipoprotein cholesterol had no significant differences(P>0.05).Conclusion The rs8193036 polymorphism of IL-17A gene promoter is associated with the pathogenesis of coronary heart disease.The C allele is an important genetic marker of coronary heart disease.The polymorphism of IL-17A promoter rs8193036 might affect coronary heart disease by increasing blood lipids and inflammation factors.
作者
张倩辉
谢悦陶
党懿
苑可心
刘月欣
李树仁
ZHANG Qianhui;XIE Yuetao;DANG Yi;YUAN Kexin;LIU Yuexin;LI Shuren(Department of Vasculocardiology,Hebei People′s Hospital,Shijiazhuang,Hebei 050000,China)
出处
《重庆医学》
CAS
2018年第11期1457-1459,1464,共4页
Chongqing medicine
基金
河北省医学科学研究重点课题(20170019)
