摘要
目的探讨影响大肠癌肝转移患者术后近期疗效的相关因素。方法选取2004年2月至2014年1月收治的大肠癌肝转移患者119例,依据手术后的复发情况分为早期复发组(术后1年内复发)和非早期复发组,比较2组患者的中位生存时间及临床资料,并进行多因素Logistic回归分析。结果早期复发38例,其中吻合口复发2例,脏器复发36例(单脏器复发29例,多脏器复发7例),随访过程中死亡18例。早期复发组中位生存时间为(17.98±3.56)个月,非早期复发组中位生存时间为(32.06±9.27)个月,差异有统计学意义(P<0.05)。2组患者的病理类型、T分期、分化程度、术前癌胚抗原及淋巴结转移情况差异有统计学意义(P<0.05)。对单因素分析中差异有统计学意义的因素进行多因素Logistic回归分析,结果显示病理类型、T分期、淋巴结转移是影响大肠癌肝转移患者外科治疗后早期复发的独立危险因素(P<0.05)。结论大肠癌肝转移患者外科治疗后的早期复发以单脏器复发为主,其中病理类型、T分期、淋巴结转移是影响早期复发的独立危险因素。
Objective To investigate the related factors of short-term curative effect in patients with liver metastasis of colorectal cancer.Methods A total of 119 patients with colorectal cancer were selected from February 2004 to January 2014,which were divided into early relapse group(relapse within 1 year)and non-early relapse group according to the recurrence status after receiving operation.The median survival time,clinical data were compared in the two groups,and conducted Logistic regression analysis.Results Early recurrence was happened to 38 patients,anastomotic recurrence was happened to 2 cases,36 cases with organ recurrence(single organ recurrence was happened to 29 cases,7 cases with multiple organ recurrence),18 cases dead during follow-up.The median survival time in early relapse group and non-early relapse group were(17.98±3.56),(32.06±9.27)months respectively,the difference was statistically significant(P<0.05).Pathological types,T stage,degree of differentiation,preoperative carcinoembryonic antigen and lymph node metastasis in the two groups were significant different(P<0.05).Logistic regression analysis showed that pathological type,T stage,lymph node metastasis were independent risk factors affecting the surgical treatment of colorectal cancer patients with liver metastasis of early recurrence(P<0.05).Conclusion Early recurrence of colorectal liver metastases after operation were single organ recurrence,the pathological type,T stage,lymph node metastasis were independent risk factors for early recurrence.
作者
王振新
李端明
WANG Zhenxin;LI Duanming(Department of General Surgery,E′gang Hospital,E′zhou,Hubei 436000,China)
出处
《检验医学与临床》
CAS
2018年第8期1067-1069,1073,共4页
Laboratory Medicine and Clinic
关键词
大肠癌
肝转移
复发
因素
colorectal cancer
liver metastases
recurrence
factor
