摘要
目的观察脑血康片辅助控制性减压术治疗重型颅脑损伤的疗效及对脑脊液中内皮素4(ET-1)和神经元特异性烯醇化酶(NSE)水平的影响。方法选择重型颅脑损伤患者98例,采用随机数字表法分为对照组49例和观察组49例。对照组采取控制性减压术治疗。观察组在对照组基础上予脑血康片治疗。比较两组格拉斯哥昏迷(GCS)评分、并发症发生情况和疗效。检测两组脑脊液中ET4和NSE水平。结果治疗后,观察组患者的GCS评分在疗后1周、疗后2周、疗后3周及疗后4周均明显高于对照组(t分别为-4.579,-5.534,-5.532,-6.632,均P<0.01)。观察组良好率为55.10%,明显高于对照组26.53%(χ~2=8.279,P<0.01)。观察组并发症发生率为36.73%,明显低于对照组75.51%(χ~2=14.959,P<0.01)。治疗后,观察组患者脑脊液中ET-4和NSE含量明显低于对照组(t值分别为15.646和8.695,P<0.01)。结论脑血康片辅助控制性减压术治疗重型颅脑损伤的疗效确切,下调患者脑脊液中ET-1和NSE含量可能与其疗效有关。
Objective To explore the effect of controlling decompression combined with Naoxuekang tablets in treating severe craniocerebral trauma and the influence on the levels of endothelin-1(ET-1)and neuron-specific enolase(NSE)in cerebrospinal fluid.Methods Ninety-eight patients with severe craniocerebral trauma were selected and randomly assigned into control group and observation group with 49 cases in each group.Control group was treated with controlling decompression while observation group was given with Naoxuekang tablets on the basis of controlling decompression.Glasgow coma scale(GCS),complication occurrence,and efficacy were compared between two groups.ET-1 and NSE in cerebrospinal fluid were detected in both groups.Results After 1 week′,2 weeks′,3 weeks′,and 4 weeks′treatment,GCS of observation group was obviously higher than control group respectively(t=-4.579,-5.534,-5.532,and-6.632 respectively,P<0.01).Good rate of observation group(55.10%)was superior to control group(26.53%)(χ2=8.279,P<0.01).Incidence of complications of observation group was 36.73%,which was evidently lower than that in control group(75.51%)(χ2=14.959,P<0.01).ET-1 and NSE in cerebrospinal fluid were lower than those in the control group with statistical significance after treatment(t=15.646,8.695,P<0.01).Conclusions The effect of controlling decompression combined with Naoxuekang tablets in treating severe craniocerebral trauma is significant,and may be relevant to the down-regulation of ET-1 and NSE in cerebrospinal fluid.
作者
付伟
周赤忠
潘德锐
FU Wei;ZHOU Chizhong;PAN Derui(Department of Neurosurgery,Puren Hospital of Wuhan,Wuhan,Hubei 430080,China)
出处
《安徽医药》
CAS
2018年第5期975-978,共4页
Anhui Medical and Pharmaceutical Journal
关键词
脑血康片
控制性减压术
重型颅脑损伤
Naoxuekang tablets
controlling decompression
severe craniocerebral trauma
