摘要
目的探讨茴拉西坦对精神分裂症行无抽搐电休克(MECT)治疗所致记忆障碍恢复时间的影响。方法选择于2015年1月—2016年12月在徐州精神病院进行MECT治疗的住院精神分裂症男性患者60例,将其采用随机数的表法分为对照组和研究组各30例,对照组采用常规治疗(抗精神病药物联合MECT),研究组在常规治疗基础上治疗前1周给予茴拉西坦。应用韦氏记忆量表测定两组患者各阶段(治疗前、治疗结束时、结束后1周、结束后2周、结束后4周)的记忆商数。结果 MECT治疗前,研究组与对照组的记忆商数比较差异无统计学意义(P>0.05);治疗结束时,研究组与对照组的记忆商数比较差异无统计学意义(P>0.05);MECT治疗后1周,研究组的记忆商数为(84.86±8.19),明显比对照组的(79.87±5.54)高,组间差异有统计学意义(P<0.05);MECT治疗后2周,研究组的记忆商数为(86.27±7.89),和对照组的(82.50±6.72)比较显著升高,组间差异有统计学意义(P<0.05)。结论茴拉西坦可以缩短精神分裂症MECT治疗所致记忆障碍的恢复时间,可能对记忆障碍的恢复有良好的促进作用,减轻患者的心理负担。
Objective This paper tries to investigate the effect of aniracetam on the recovery time of dysmnesia induced by modified electriconvulsive therapy(MECT)in patients with schizophrenia.Methods 60 patients with schizophreniatreated with MECT from January 2015 to December 2016 in Xuzhou psychiatric hospital were randomly divided into control group and study group(n=30).The control group received conventional therapy(Antipsychotic drugs combined with MECT).The study group was given aniracetam 1 week prior to treatment on a routine basis.The Wechsler memory scale was used to measure the memory quotient of the two groups of patients at all stages(before treatment,at the end of treatment,1 week after the end,2 weeks after the end,4 weeks after the end).Results Before MECT treatment,there was no statistically significant difference between the memory quotient of the study group and the control group(P>0.05).At the end of the treatment,there was no statistically significant difference between the memory quotient of the study group and the control group(P>0.05).1 week after MECT treatment,the memory quotient of the study group was(84.86±8.19),significantly higher than that in the control group(79.87±5.54),and the difference between groups was significant(P<0.05).2 weeks after MECT treatment,the memory quotient of the study group was(86.27±7.89),and the control group was(82.50±6.72),significantly higher,with significant difference between groups(P<0.05).Conclusion Aniracetam can shorten the recovery time of dysmnesia caused by MECT in schizophrenic patients,which may promote the recovery of dysmnesia and reduce the psychological burden of patients.
作者
池雷
王婷
陈雪
CHI Lei;WANG Ting;CHEN Xue(Xuzhou Mental Hospital,Xuzhou,Jiangsu Province,221006 China;Soochow University,Suzhou,Jiangsu Province,215123 China)
出处
《系统医学》
2017年第21期20-21,24,共3页
Systems Medicine
