摘要
目的:比较输卵管妊娠时,单纯输卵管开窗术、手术及局部使用甲氨蝶呤治疗后的卵巢激素水平指标,以探讨不同治疗方式对输卵管妊娠患者卵巢储备功能的影响。方法:将确诊输卵管异位妊娠的94例患者分为两组,腹腔镜下开窗取胚术(A组)患者48例,腹腔镜下开窗取胚术加局部注射甲氨蝶呤患者(B组)46例。确诊后至治疗输卵管妊娠前,检测患者静脉血抗苗勒管激素(AMH),治疗结束后1个月、6个月于患者的月经第2~3天检测血AMH、性激素(FSH、E2)水平。结果:两组患者持续性异位妊娠发生率比较,差异无统计学意义(χ2=1.958,P=0.162);术后AMH值是逐步下降的,且各时间点数值不随分组的不同而不同,但只有术后6个月与术前AMH值比较,差异有统计学意义(P=0.001)。不同时间点、组间的FSH、E2比较,差异均无统计学意义(P>0.05)。结论:治疗输卵管妊娠时,输卵管开窗取胚术不足以引起卵巢储备功能减低,局部使用甲氨蝶呤治疗不会影响卵巢储备功能。
ObjectiveTo objective the ovarian reserve function in patients with tubal pregnancy,using laparoscopic salpingostomy and local use of methotrexate in the treatment of tubal pregnancy.Method 94cases of tubal ectopic pregnancy confirmed in the maternal and child health hospital were randomly divided into two groups.48 cases of patients used laparoscopic salpingostomy(group A).46 patients underwent laparoscopic salpingostomy and local injection of methotrexate.After thediagnosis of tubal pregnancy,detecting serum AMH before the treatment.1 month,6 months after treatment,the levels of sex hormone(FSH,E2)were measured.Results There was no significant difference in the incidence of persistent ectopic pregnancy between two groups(χ2=1.958,P=0.162).The postoperative AMH were gradually decreased,and the values were not different with two groups.The value of AMH was statistically different between 6 months after operation and before operation(P=0.001).There was no difference in FSH and E2 between different time and groups.Conclusion In the treatment of tubal pregnancy,laparoscopic salpingostomy is not enough to cause ovarian reserve function reduction.Local use of methotrexate will not affect the ovarian reserve function.
作者
易灵
刘群英
唐愿映
黄文静
崔艳萍
胡庆兰
YI Ling;LIU Qun-ying;TANG Yuan-ying(Maternal and Child Health Care Hospital of Qingyuan,Qingyuan 511500,China)
出处
《吉林医学》
CAS
2018年第4期623-625,共3页
Jilin Medical Journal
基金
广东省清远市科技局自筹经费项目[项目编号:2016B082]
关键词
输卵管妊娠
卵巢储备功能
甲氨蝶呤
抗苗勒管激素
性激素
Tubal pregnancy
Ovarian reserve function
Methotrexate
Anti-mullerian hormone
Sex hormone
