摘要
目的:研究分析不同剂量的硼替佐米治疗多发性骨髓瘤的疗效对比。方法:选取我院收治的40例多发性骨髓瘤患者为研究对象。对照组给予1.0 mg/m^2的低剂量硼替佐米治疗。实验组给予1.3 mg/m^2剂量硼替佐米治疗。结果:实验组中,完全缓解患者为8例,所占比例为40.0%,部分缓解患者为9例,无变化患者为2例,病情进展患者为1例。对照组,病情进展患者为3例,3例患者无变化。实验组治疗有效率为85.0%,对照组治疗有效率为70.0%,具有统计学差异(P<0.05)。对照组中,1例发生血小板减少,1例皮疹,1例乏力,2例肠胃道反应。实验组与对照组患者不良反应发生率分别为30.0%与25.0%,不具有统计学差异(P>0.05)。结论:多发性骨髓瘤中应用1.3mg·m^(-2)·d^(-1)剂量的硼替佐米临床治疗效果较为理想,能够帮助患者尽快达到缓解,耐受良好,具有临床推广的意义。
Objective:To study and analyze the effect of different doses of bortezomib in the treatment of multiple myeloma.Methods:40 cases of multiple myeloma treated in our hospital were selected as the subjects.The control group was treated with low dose bortezomib(1.0mg/m 2).The experimental group was treated with bortezomib with 1.3mg/m 2dose.Results:in the experimental group,8 cases of complete remission were found,accounting for 40%,9 cases of partial remission,2 cases of no change,1 cases of disease progression.In the control group,3 cases were progressed and 3 patients had no change.The effective rate of treatment in the experimental group was 85%,and the effective rate in the control group was 70%,with statistical difference(P<0.05).In the control group,there were 1 cases of thrombocytopenia,1 cases of rash,1 cases of fatigue,and 2 cases of gastrointestinal reaction.The incidence of adverse reactions between the experimental group and the control group was 30%and 25%,respectively,and there was no statistical difference(P>0.05).Conclusion:As the dose of bortezomib in the treatment of multiple myeloma is 1.3mg/m 2.d,the clinical effect is ideal,it can help patients achieveremission as soon as possible,and has the significance of clinical promotion.
作者
刘林
李佳佳
张凤
LIU Lin;LI Jiajia;ZHANG Feng(Dept.of Hematology,First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)
出处
《泰山医学院学报》
CAS
2018年第4期415-416,共2页
Journal of Taishan Medical College
