摘要
目的目前国内运用胃蛋白酶诊断咽喉反流的研究相对较少。文中旨在通过对慢性咽炎患者进行唾液/痰液胃蛋白酶检测,评价胃蛋白酶检测方法在咽喉反流诊断中的应用价值。方法选取2017年1月至6月于南京军区南京总医院耳鼻咽喉头颈外科就诊的35例慢性咽炎患者。进行电子喉镜检查、反流检查计分量表(RFS)评分、反流症状指数量表(RSI)评分,同时对患者的唾液/痰液行胃蛋白酶浓度的检测(PEPTEST检测),共收集受试者3次唾液/痰液样本,第1次为晨起未漱口之前,第2次为午餐后1 h,第3次为症状明显时收集样本。将上述检查结果进行对比研究。结果 RSI、RFS平均为(11.31±6.21)、(5.97±1.98)分。晨起唾液/痰液中胃蛋白酶含量[26.80(0,109.80)ng/m L]较午餐后1 h[89.00(16.0,254.8)ng/m L]、症状明显时[105.70(34.3,254.8)ng/m L]明显降低(P<0.05)。胃蛋白酶值诊断咽喉反流的ROC曲线下面积晨起[0.759(0.602,0.917)]、午餐后1 h[0.824(0.670,0.978)]、症状明显时[0.873(0.725,1.000)]均大于RSI联合RFS,差异有统计学意义(P<0.05)。结论与传统方法(RFS评分联合RSI评分)相比,胃蛋白酶检测方法在咽喉反流诊断中具有更重要的临床价值。
Objective At present,there are relatively few studies on the application of pepsin in the diagnosis of laryngopharyngeal reflux disease(LPRD)in China.This paper aimed to evaluate the application value of Peptest in the diagnosis of LPRD by measuring saliva/sputum pepsin in patients with chronic pharyngitis.Methods From January to June 2017,35 patients with chronic pharyngitis treated in our department were selected to undertake electronic laryngoscopy and evaluated by reflux finding score(RFS)and reflux symptom index(RSI)scoring.The patients'saliva/sputum samples were collected three times for pepsin concentration detection(PEPTEST).The first collection was before mouthwash in the morning,the second was 1h after lunch,and the third was the time of evident symptoms.Comparative research was carried out on the above results.Results The average RSI score and RFS score were11.31±6.21 and 5.97±1.98.The pepsin content in morning saliva/sputum[26.80(0,109.80)ng/mL]was significantly lower than that at 1 h after lunch[89.00(16.0,254.8)ng/mL]and that at the time of obvious symptoms[105.70(34.3,254.8)ng/mL](P<0.05).The area under ROC of Peptest in the morning[0.759(0.602,0.917)],1h after lunch[0.824(0.670,0.978)],at the time of obvious symptoms were all greater than the combination of RSI and RFS,representing significant statistical differences(P<0.05).Conclusion Compared with traditional method(a combination of RSI and RFS),Peptest has more important clinical value in the diagnosis of LPRD.
作者
王秀
李益飞
陈伟
许莉
吴明海
张勇
季俊峰
王秋萍
WANG Xiu;LI Yi-fei;CHEN Wei;XU Li;WU Ming-hai;ZHANG Yong;JI Jun-feng;WANG Qiu-ping(Department of Otolaryngology-Head and Neck Surgery,Jingling Hosptal,Nanjing University School of Medicine/Nanjing General Hospital of Nanjing Military Region,PLA,Nanjing 210002,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2018年第4期408-411,共4页
Journal of Medical Postgraduates
基金
江苏省青年医学重点人才基金(QNRC2016917)
关键词
咽喉反流
慢性咽炎
胃蛋白酶
chronic pharyngitis
laryngopharyngeal reflux disease
pepsin
