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氯碘羟喹乳膏治疗婴儿念珠菌性间擦疹临床和实验研究 被引量:1

Clinical and experimental research of using topical clioquinol cream to treat infantile candidal intertrigo
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摘要 患儿因会阴部红斑瘙痒7d就诊。皮肤科检查示会阴部红斑。皮肤镜下可见红色基底上黄白色鳞屑。粘取皮损直接镜检,沙堡弱培养基、科玛嘉显色培养基培养,芽管实验及提取DNA扩增后测序鉴定,确诊为白念珠菌致念珠菌性间擦疹。用药前后用无菌敷贴粘取对称部位鳞屑,置于同一培养基内培养,用药后一侧无菌落生长。用改良琼脂扩散法进行药敏实验证实3%氯碘羟喹乳膏良好的抑菌作用。镜检阳性后立即给与3%氯碘羟喹乳膏外用,用药后皮损明显好转,复查镜检和培养均阴性。3%氯碘羟喹乳膏可作为临床外用抗真菌药物选择。真菌荧光染液处理鳞屑能清晰判断菌丝及孢子,实验技术的革新有利于患者的诊断及治疗。 Two children consulted our clinic for erythema and itch for 7 days.Physical examination showed erythema on the perineum.Dermoscopy showed red base with yellow-white scales.Based on the direct microscopic examination,culture on Sabouraud dextrose agar and chromogenic candida agar,serum tube assay and DNA extracted PCR-sequencing identification,candidal intertrigo due to C.albicans was made.Using sterile patch to obtain scales from left side of the crissum before medication,the same method to obtain scales from right side of the crissum after first medication,then put two patches in the same culture medium.The side of sterile patch after medication with sterile cotton(the right side of crissum)showed no colony.Then we used modified agar diffusion method to identify good antifungal activity of 3%clioquinol cream.Cliquinol cream was used in the patient after positive results of direct microscopic examination.The skin lesion was obviously improved and no hyphae or spore were found in the microscopic observation.3%clioquinol cream can be an option of topical antifungal formulations.Samples prepared with fungal fluorescence staining solution made easier to find hyphae or spore.The innovation of laboratory technique was benefit for diagnose and treatment of patient.
作者 游紫梦 冉昕 代亚玲 冉玉平 YOU Zi-meng;RAN Xin;DAI Ya-ling;RAN Yu-ping(Department of Dermatoverenology,West China Hospital;Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China)
出处 《中国真菌学杂志》 CSCD 2018年第1期26-29,共4页 Chinese Journal of Mycology
关键词 氯碘羟喹 念珠菌性间擦疹 白念珠菌 皮肤镜 clioquinol candidal intertrigo C.albicans dermoscopy
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