摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝损伤,疾病谱包括非酒精性肝脂肪变(non-alcoholic hepatic steatosis)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、肝硬化和肝细胞癌(hepatocellular carcinoma,HCC)[1-2]。NAFLD不仅可以导致肝病残疾和死亡,还与代谢综合征(metabolic syndrome,MetS)、2型糖尿病(type 2 diabetes mellitus,T2DM)、动脉硬化性心血管疾病以及结直肠肿瘤等的高发密切相关。随着肥胖和MetS的流行,NAFLD已成为我国第一大慢性肝病和健康体检肝脏生物化学指标异常的首要原因。并且,越来越多的乙型肝炎病毒(hepatitis B virus,HBV)慢性感染者合并NAFLD[3-5],严重危害人民生命健康。
作者
无
范建高
魏来
庄辉
National Workshop on Fatty Liver and Alcoholic Liver Disease,Chinese Society of Hepatology,Chinese Medical Association;Fatty Liver Expert Committee,Chinese Medical Doctor Association;Fan Jiangao;Wei Lai;Zhuang Hui(Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;Hepatology Insititute,People’s Hospital,Peking University,Beijing 100044,China;Peking University School of Medicine,Beijing 100191,China)
出处
《实用肝脏病杂志》
CAS
2018年第2期177-186,共10页
Journal of Practical Hepatology
关键词
脂肪肝
诊断
治疗
代谢综合征
指南
Fatty liver
Diagnosis
Therapy
Metabolic syndrome
Guidebooks