摘要
目的:观察分析拉贝洛尔联合硝苯地平治疗子痫前期的疗效与不良反应。方法:选取本院2013年1月-2016年6月收治的95例子痫前期患者,按照随机数字表法分为观察组(n=50)和对照组(n=45)。两组均予常规护理并采用硫酸镁治疗,对照组加用硝苯地平,观察组在其基础上配合拉贝洛尔治疗。观察两组的疗效,记录比较两组的血压变化、24 h尿蛋白、妊娠延长时间,比较两组围生期的不良反应。结果:观察组疗效优于对照组,差异有统计学意义(P<0.05);治疗前,两组收缩压(SBP)、舒张压(DBP)、24 h尿蛋白量比较,差异均无统计学意义(P>0.05);治疗后,观察组SBP、DBP、24 h尿蛋白量均低于对照组,差异均有统计学意义(P<0.05);与对照组比较,观察组妊娠时间长,新生儿窒息、胎儿宫内窘迫发生率低,差异均有统计学意义(P<0.05);两组不良反应发生率、产后出血率比较,差异均无统计学意义(P>0.05)。结论:在子痫前期运用硝苯地平联合拉贝洛尔治疗效果明显,能够有效缓解临床症状,降低产妇血压,延长妊娠时间,减少并发症。
Objective:To observe the effect and adverse reaction of Labetalol combined with Nifedipine in the treatment of preeclampsia.Method:In our hospital from January 2013 to June 2016,95 patients with preeclampsia treated in our hospital,they were randomly divided into observation group(n=50)and control group(n=45).Two groups were given routine nursing care and Magnesium Sulfate treatment,the control group was treated with Nifedipine,the observation group was given Labetalol on the basis of the control group.The efficacy of two groups were recorded,blood pressure changes were compared between two groups,24 hours urinary protein,prolonged pregnancy,perinatal adverse reactions were compared between two groups.Result:The total effective rate of the treatment group was better than that of the control group,the difference was statistically significant(P<0.05).Before treatment,systolic blood pressure(SBP),diastolic blood pressure(DBP),and 24 hours urinary protein of two groups had no significant differences(P>0.05).After treatment,SBP,DBP,and 24 hours urinary protein of the treatment group were lower than those of the control group,the differences were statistically significant(P<0.05).Compared with the control group,the pregnancy time,neonatal asphyxia,fetal distress incidence rate of the observation group were lower,the differences were statistically significant(P<0.05).The adverse reactions and the rate of postpartum hemorrhage of two groups,there were no statistical significance(P>0.05).Conclusion:Preeclampsia treated with Nifedipine combined with Labetalol treatment has obvious effect,can effectively relieve clinical symptoms,reduce the maternal blood pressure,prolong pregnancy time,reduce complications.
作者
孙丹
SUN Dan(Hanchuan People’s Hospital,Hanchuan 431600,China)
出处
《中国医学创新》
CAS
2018年第5期53-56,共4页
Medical Innovation of China
基金
湖北省卫生厅科研基金资助项目(JX3B52)
