摘要
目的:探讨使用不同剂量硫酸镁治疗中重度妊娠期高血压疾病患者的临床疗效。方法:选取本院中重度妊娠期高血压疾病患者60例,按照随机数字表法分为对照组和观察组,各30例。两组均采用降压、镇静、利尿治疗,对照组同时给予普通剂量硫酸镁肌注或静脉滴注,观察组给予负荷剂量硫酸镁推注,再以静脉滴注维持,必要时再给予肌注,观察1~3 d。比较两组观察期血压、分娩方式、并发症、Apgar评分及羊水性质。结果:观察第1~3天,两组血压均呈不同程度下降,但观察组血压较对照组下降明显(P<0.05);观察组Apgar评分及羊水性质均优于对照组,但比较差异均无统计学意义(P>0.05);60例产妇中自然分娩出院5例(观察组2例,对照组3例),未分娩出院3例(观察组2例,对照组1例);剖宫产52例(观察组26例,对照组26例);观察组并发症发生率为3.57%(1/28),低于对照组的17.24%(5/29),但比较差异无统计学意义(P>0.05)。结论:中重度妊娠期高血压疾病患者给予负荷剂量硫酸镁治疗时的疗效较普通剂量更加显著,同时能够有效防止一系列并发症的发生,使患者血压下降更稳定,更明显,具有临床使用及推广意义。
Objective:To explore the clinical efficacy of different doses of Magnesium Sulfate in treatment of moderate and severe hypertensive disorder complicating pregnancy.Method:A total of 60 patients with moderate and severe hypertensive disorder complicating pregnancy in our hospital were selected.According to the random number table method,they were divided into control group and observation group,30 cases in each group.They were treated with depressor,sedative and diuretic treatment,while control group was given the common dose of Magnesium Sulfate muscle injection or intravenous drip,and observation group was injected with a load dose of Magnesium Sulfate,and then maintained by intravenous drip,and the intramuscular injection was given when necessary,observation of 1-3 d.The blood pressure,delivery mode,complications,Apgar score and nature of amniotic fluid of two groups were compared.Result:After 1-3 d,the blood pressure of two groups decreased in varying degrees,but the blood pressure of observation group was significantly lower than that of control group(P<0.05).Apgar score and nature of amniotic fluid in observation group were all better than those of control group,but the differences were not statistically significant(P>0.05).5 cases of natural labor and leave hospital(2 cases in observation group and 3 cases in control group),3 cases were discharged from discharge(2 cases in observation group,1 cases in control group)and 52 cases of cesarean section(26 cases in observation group and 26 cases in control group).The incidence of complications in observation group was 3.57%(1/28),which was lower than 17.24%(5/29)of control group,but the difference was not statistically significant(P>0.05).Conclusion:The effect of the load dose Magnesium Sulfate in treatment of moderate and severe hypertensive disorder complicating pregnancy is more significant than that of the normal dose,meanwhile,it can effectively prevent a series of complications,and make blood pressure drop more stable and more obvious,which has clinical app
作者
朱义芳
ZHU Yifang(First People’s Hospital of Jingdezhen,Jingdezhen 333000,China)
出处
《中国医学创新》
CAS
2017年第35期52-55,共4页
Medical Innovation of China
关键词
妊娠期高血压疾病
硫酸镁
负荷治疗
Hypertensive disorder complicating pregnancy
Magnesium sulphuricum
Load therapy
