摘要
目的:探究噻托溴铵治疗尘肺并发慢性阻塞性肺疾病的临床效果。方法:选取2016年2月-2017年6月在本院诊治的尘肺并发慢性阻塞性肺病患者94例作为研究对象,对照组进行常规治疗,观察组在对照组基础上采用噻托溴铵进行治疗。比较两组治疗效果、治疗前后的肺功能指标和血气指标、不良反应发生情况等。结果:观察组治疗总有效率为93.62%,高于对照组的74.47%,比较差异有统计学意义(P<0.05)。治疗前两组肺功能指标比较,差异均无统计学意义(P>0.05);治疗后两组肺功能指标均较治疗前得到不同程度改善,比较差异均有统计学意义(P<0.05);治疗后观察组肺活量、每分钟通气量、最大通气量等均优于对照组,比较差异均有统计学意义(P<0.05)。治疗后两组血气指标均较治疗前得到不同程度改善,比较差异均有统计学意义(P<0.05);且观察组p H值、动脉血氧分压、动脉血氧饱和度均优于对照组,比较差异均有统计学意义(P<0.05)。治疗前两组生命体征比较,差异均无统计学意义(P>0.05);治疗后观察组生命体征均显著优于对照组,比较差异均有统计学意义(P<0.05)。观察组不良反应发生率为8.51%(4/47),对照组为6.38%(3/47),比较差异无统计学意义(P>0.05)。结论:噻托溴铵在尘肺并发慢性阻塞性肺病的治疗中具有良好的临床效果,用药安全,可推广使用。
Objective:To study the clinical effect of Tiotropium Bromide in treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease.Method:94 cases of pneumoconiosis complicated with chronic obstructive pulmonary disease were treated in our hospital from February 2016 to June 2017 were selected as the subjects.The control group was given conventional treatment,and observation group was treated with Tiotropium Bromide on the basis of control group.The curative effect,lung function indexes and blood gas indexes before and after treatment and adverse reactions were compared between two groups.Result:The total effective rate of observation group was 93.62%higher than 74.47%of control group,the difference was statistically significant(P<0.05).Before treatment,the lung function indexes of two groups were compared,the differences were not statistically significant(P>0.05).After treatment,the lung function indexes of the two groups were improved to varying degrees compared with before treatment,the differences were statistically significant(P<0.05);after treatment,the vital capacity,ventilation volume per minute and maximum ventilation volume of observation group were better than those of control group,the differences were statistically significant(P<0.05).After treatment,the blood gas indexes of two groups were improved to varying degrees,the differences were statistically significant(P<0.05);the pH value,arterial partial pressure of oxygen and arterial oxygen saturation in observation group were better than those of control group,the differences were statistically significant(P<0.05).Before treatment,the vital signs of two groups were compared,the differences were not statistically significant(P>0.05);after treatment,the vital signs of observation group were significantly better than those of control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions was 8.51%(4/47)in observation group and 6.38%(3/47)in control group,the difference was not statistically signif
作者
陈达明
陈国伟
CHEN Da-ming;CHEN Guo-wei(Yangdong People’s Hospital,Yangjiang 529500,China)
出处
《中国医学创新》
CAS
2017年第31期24-28,共5页
Medical Innovation of China
