摘要
目的检测不同强度有氧训练前后脑卒中患者凝血六项,探讨不同强度有氧运动对脑卒中凝血功能的影响。方法收集2015年1月至2016年12月在重庆市肿瘤医院脑外科初发脑卒中患者120例,根据心肺运动试验,结合随机数字表法将患者分为中强度有氧运动组、低强度有氧运动组及对照组。对照组维持神经内科初发脑卒中基本药物等治疗,中强度有氧运动组、低强度有氧运动组在对照组基础上,以不同强度踩踏功率自行车进行训练。分析比较3组间运动训练前后凝血六项[血浆纤维蛋白原(FIB)、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、国际标准化比值(INR)和凝血酶时间(TT)]指标的差异。结果结果显示3组间运动训练前凝血指标差异无统计学意义(P>0.05)。中强度组运动训练后FIB、D-D水平显著低于训练前,低强度组运动训练后仅有FIB水平显著低于训练前,且差异具有统计学意义(P<0.05);中强度组、低强度组其余指标运动前后差异无统计学意义(P>0.05)。对照组基础治疗前后各凝血指标差异无统计学意义(P>0.05)。运动训练后,中强度组FIB水平显著低于低强度组,而低强度组显著低于对照组,且差异具有统计学意义(P<0.05)。结论中、低强度有氧运动可在一定程度上影响脑卒中患者凝血功能,其中中强度有氧运动更为显著,为临床科学、个体化有氧运动结合药物防治脑卒中再发提供了科学依据。
Objective The effects of different intensity aerobic exercise on the coagulation function of stroke were investigated by detection coagulation index of stroke patients before and after different intensity of aerobic training.Methods 120 patients with neurological initial stroke were enrolled from January to December in 2016.According to the cardiopulmonary exercise test,the patients were divided into medium-intensity aerobic exercise group,low-intensity aerobic exercise group and control group.The control group maintained the basic medical treatment of neurological primary stroke.The medium-intensity aerobic exercise group and low-intensity aerobic exercise group were on the basis of the control group with different intensity by stampeding power bike training.The plasma fibrinogen(FIB),D-Dimer(D-D),activated partial thromboplastin time(APTT),prothrombin time(PT),international normalized ratio(INR)and thrombin time(TT)were detected and analyzed before and after exercise training.Results The results showed there were no significant difference in coagulation index between the three groups before exercise training(P>0.05).The levels of FIB and D-D in medium-intensity aerobic exercise group after the training were significantly lower than before the training(P<0.05).The levels of FIB in low-intensity aerobic exercise group after the training were significantly lower than before the training(P<0.05).There were no significant difference between in others coagulation index between two groups(P>0.05).There were no significant difference in coagulation index between before and after the basic treatment in control group(P>0.05).After exercise training,the levels of FIB in the moderate intensity group was significantly lower than the low intensity group(P<0.05),and then the low intensity group was significantly lower than control group(P<0.05).Conclusion The medium and low-intensity aerobic exercise could influence the coagulation function of stroke patients,particularly in the medium-intensity.It provided the scientific bas
作者
杨清堂
段永亮
吴雅竹
YANG Qingtang;DUAN Yongliang;WU Yazhu(Department of Clinical Laboratory,the Affiliated Cancer Hospital of Chongqing University/the Institute of Cancer Research of Chongqing/Chongqing Cancer Hospital, Chongqing 400030,China;Department of Clinical Laboratory,Qijiang District People′s Hospital, Chongqing 401420,China;Department of Internal,Traditional Chinese Medical Hospital,Shapingba District,Chongqing 400030,China)
出处
《国际检验医学杂志》
CAS
2018年第7期837-839,843,共4页
International Journal of Laboratory Medicine
关键词
脑卒中
凝血功能
有氧运动
cerebral stroke
coagulation function
aerobic exercise
