摘要
恶性疟原虫引起的恶性疟疾是一种严重危害人类健康的寄生虫病,采用疫苗防治该病是当前研究的热点领域之一。PfCSP、PfMSP-1、PfAMA1、Pfs25、PfTRAP和PfME-TRAP等抗原是几种有效的疫苗候选分子,本文综述了鼠伤寒沙门氏菌、乳酸乳球菌、卡介苗、耻垢分枝杆菌、酵母菌、根癌农杆菌、葡萄球菌、嗜热四膜菌、腺病毒、牛痘病毒、杆状病毒、黄热病毒和A型流感病毒等微生物介导的恶性疟原虫PfCSP、PfMSP-1、PfAMA1、Pfs25、PfTRAP和PfME-TRAP疫苗的研制现状。
Plasmodium falciparum infection may results in Falciparum malaria.Developing vaccine against this parasitic disease is the recent research trend.PfCSP,PfMSP-1,PfAMA1,Pfs25,PfTRAP and PfME-TRAP antigen are many types of candidate vaccine molecules,the review outlines the status in the research of microorganisms-vectored vaccine against Plasmodium falciparum,this vectors include:bacteria such as Salmonella typhimurium,Lactococcus lactis,Bacillus calmette-Guerin,Mycobacteria smegmatis,Pichia pastoris,Agrobacterium tumefaciens,Staphylococcus and Tetrahymena thermophila,viruses such as Adenovirus,Vaccinia virus,Baculovirus,Fellow fever Virus and Influenza Virus A.
作者
李文桂
陈雅棠
LI Wengui;CHEN Yatang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)
出处
《国外医学（医学地理分册）》
CAS
2018年第2期89-97,共9页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学基金(No.30801052
30671835
30500423
30200239)
关键词
恶性疟原虫
抗原
疫苗
综述
Plasmodium falciparum
antigen
vaccine
review
