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方剂联合离子导入在高尿酸、痛风患者中的应用及对TNF-α、IL-1和IL-6水平影响研究 被引量:3

Application of Bushen Tiaogan Huoxue decoction in oral and ion implantation in patients with hyperuricemia and gout and its influence on inflammatory factors in peripheral blood
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摘要 目的:探讨补肾调肝活血利湿方内服及离子导入在高尿酸血症及痛风患者中的临床效果及对外周炎症因子的影响。方法:收治高尿酸血症及痛风患者180例,随机数字法分为对照组(n=90)和药物联合组(n=90)。对照组采用苯溴马隆治疗,药物联合组采用中药汤剂温服及中药离子导入治疗,采用酶联免疫吸附试验测定两组治疗前、后TNF-α、IL-1和IL-6水平,比较两组临床疗效及对外周血中炎症因子的影响。结果:药物联合组治疗后1年疗效率为90.00%,与对照组66.67%比较差异有统计学意义(P<0.05)。两组治疗前TNF-α、IL-1和IL-6水平比较差异无统计学意义(P>0.05)。药物联合组治疗后1年TNF-α、IL-1和IL-6水平,低于对照组(P<0.05)。药物联合组治疗后1年关节疼痛、关节肿胀及关节僵硬症状积分,高于对照组(P<0.05)。结论:高尿酸血症及痛风患者采用补肾调肝活血利湿方内服及离子导入治疗效果理想。 Objective:To explore the effect of invigorating kidney and regulating liver and activating blood circulation and removing dampness medicine iontophoresis in the clinical effect of hyperuricemia and gout in patients with peripheral inflammatory factors.Methods:Total of 180 patients with hyperuricemia and gout were treated.The patients were randomly divided into two groups:control group(n=90)and drug combination group(n=90).The control group using benzyl bromide Malone treatment,combined drug group were treated with traditional Chinese medicine decoction.And the traditional Chinese medicine iontophoresis,2 groups before and after treatment,TNF-α、IL-1 and IL-6 levels were measured by enzyme-linked immunosorbent assay,inflammatory factors and clinical effects of the 2 groups in peripheral blood.Results:The drug combined treatment group after 1 years of treatment efficiency was 90%,there was statistically significant difference compared with the control group of 66.67%(P<0.05).TNF-α、IL-1 and IL-6 levels had no significant difference between the 2 groups before treatment(P>0.05).Drug combined treatment group after 1 years of TNF-α、and IL-1 and IL-6 levels lower than the control group(P<0.05).Drug combined treatment group after 1 years of joint pain,joint swelling and stiffness of the joint symptoms score higher than the control group(P<0.05).Conclusion:Hyperuricemia and gout patients with ideal treatment effect of invigorating kidney and regulating liver and activating blood circulation and removing dampness by iontophoresis,it is worthy of popularization and application.
作者 张永健 朱立春 王海龙 梅冬艳 薛秀娟 Zhang Yongjian;Zhu Lichun;Wang Hailong(Qinhuangdao Hospital of Traditional Chinese Medicine in Hebei Province(Qinhuangdao 066000))
出处 《陕西中医》 2018年第3期358-360,共3页 Shaanxi Journal of Traditional Chinese Medicine
基金 河北省秦皇岛市科技支撑计划项目(201502A138)
关键词 高尿酸血症/中西医结合疗法 痛风 @中药离子导入 Hyperuricemia/integrated Chinese traditional and western medicine therapy Gout @Ion lmplarbation
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