摘要
目的:观察纤维支气管镜介入治疗对肺结核的效果及对痰菌阴转率的影响。方法:选择肺结核患者60例,随机分为研究组和对照组各30例。两组化疗方案均为2HRZE/4HR,强化期:异烟肼(H)、利福平(R)、吡嗪酰胺(Z)、乙胺丁醇(E),1次/d,共2个月;继续期:异烟肼(H)、利福平(R),1次/d,共4个月;研究组另外经纤维支气管镜导管介入病灶内注药。观察两组体重等临床症状、病灶的情况及痰菌阴转率。结果:两组患者治疗前体重比较无统计学差异(P>0.05);在第2个月和第6个月结束时,两组体重均增加,但无统计学差异(P>0.05);对照组平均痰菌阴转时间(52.5±24.5)d,而研究组为(40.6±22.5)d,研究组患者在痰菌阴转时间方面比例明显高于对照组患者(P<0.05),差异具有统计学意义;研究组患者治疗后显著吸收13例,吸收10例,不变2例,恶化1例,在病灶吸收率方面优于对照组(显著吸收12例,吸收9例,不变6例,恶化2例),两组比较差异有统计学意义(P<0.05)。结论:纤维支气管镜介入治疗肺结核痰菌阴转率增高,疗效确切。
Objective:To observe the effect of interventional therapy with fiberoptic bronchoscopy on pulmonary tuberculosis and the negative conversion rate of sputum bacteria.Methods:60 patients with pulmonary tuberculosis were randomly divided into the study group and the control group with 30 cases in each group.Two chemotherapy regimens were 2HRZE/4HR,intensive period:isoniazid(H),Li Fuping(R),pyrazinamide(Z),ethambutol(E),1 times/d,a total of 2 months;continue period:isoniazid(H),Li Fuping(R),1 times/d,a total of 4 months;research the other group by fiberoptic bronchoscopy interventional intralesional injection.The clinical symptoms such as body weight,lesion and negative conversion rate of sputum were observed in the two groups.Results:Both groups of patients before treatment,no significant differences in body weight(P>0.05);at the end of 2 months and 6 months,body weight increased in both groups,but no significant difference(P>0.05);the control group average sputum conversion time(52.5±24.5)d,and the research group(40.6±22.5)d patients,study group patients in the control group the sputum negative conversion time was significantly higher than the proportion(P<0.05),the difference was statistically significant;13 patients with significant absorption in patients of the study group after treatment,the absorption of 10 cases,unchanged 2 cases,1 cases deteriorated,the absorption rate is better than the control group in the lesion(significant absorption of 12 cases the absorption,9 cases,6 cases of 2 were unchanged,worse),the difference was statistically significant(P<0.05).Conclusion:Fiberoptic bronchoscopy in the treatment of pulmonary tuberculosis sputum negative conversion rate increased,the curative effect is exact.
作者
汪晓芹
杜超英
阳绪容
孙琳
Wang Xiaoqin;Du Chaoying;Yang Xurong(Endoscopy Center of West China Hospital,Sichuan University,Chengdu 610041)
出处
《陕西医学杂志》
CAS
2018年第3期317-319,共3页
Shaanxi Medical Journal
基金
四川省科技厅科技支撑计划项目(2012SZ00583)
关键词
结核
肺/治疗
支气管镜检查
放射学
介入性
痰
Tuberculosis,pulmonary/therapy
Bronchoscopy
Radiography,interventional
Sputum
