摘要
目的:探讨高频电子灼烧联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣的临床效果。方法:选取2015年6月至2016年6月在我院确诊治疗的尖锐湿疣患者80例为观察对象,随机分为两组,每组40人,一组使用高频电子灼烧联合5-氨基酮戊酸光动力(ALA-PDT)治疗方案(联合组),另一组采用单纯高频电离子灼烧治疗方案(电离子组),并对两组患者临床治疗效果进行分析。结果:治疗半年后,联合组PCR阴性率为62.50%,高于电离子组(χ~2=8.498,P=0.004);两组患者治疗前症状积分无差别,治疗半年后,联合组患者症状较电离子组明显改善;两组患者治疗前的炎症细胞因子水平无明显差别,治疗半年后,联合组IL-6、hs-CRP和TNF-α等水平低于电离子组(P<0.05)。结论:电离子联合ALAPDT治疗尖锐湿疣效果优于单纯使用高频电子灼烧治疗尖锐湿疣。
Objectives:To study the clinical effect of electro-ionization therapy combined with ALA-PDT in treatment of condyloma acuminatum.Methods:80 patients with condyloma acuminatum treated in our hospital from June 2015 to June 2016 were selected and randomly divided into two groups,with 40 cases in each group.One group was treated by electro-ionization therapy combined with ALA-PDT,while the other group was treated by electro-ionization therapy.The clinical effect was analyzed.Results:Half a year after treatment,the PCR negative rate of combination group was 62.50%,which was higher than electro-ionization group(χ2=8.498,P=0.004).Before treatment,the symptom score of the two groups had no significant difference.Half a year after treatment,the symptoms of combination group improved more significantly than electro-ionization group,though there was no significant difference in the levels of inflammatory cytokines in two groups before treatment.Six months after treatment,the levels of IL-6,hs-CRP and TNF-αin combination group were lower than those in the electro-ionization group(P<0.05).Conclusion:The clinical effect of electro-ionization therapy combined with ALA-PDT in treatment of condyloma acuminatum is remarkable.
作者
吴英桂
欧伟洪
WU Yingui;OU Weihong(Department of Dermatology,The 3 rd People's Hospital of Haikou,Haikou 571100,Hainan,China;Department of Dermatology,Haikou People's Hospital,Haikou 571100,Hainan,China)
出处
《中国性科学》
2018年第3期81-83,共3页
Chinese Journal of Human Sexuality
