摘要
目的:观察维持性血液透析(maintenance hemodialysis,MHD)患者C反应蛋白(C reactive protein,CRP)水平与心脑血管疾病的关系。方法:选取2014年7月—2017年7月在南通市第四人民医院血液净化中心进行MHD的尿毒症患者40例,按CRP水平判定是否存在微炎症状态分为微炎症组(n=20,CRP>6 mg/L)和非炎症组(n=20,CRP≤6 mg/L)。另选取我院同期健康体检合格者20例作为对照组。结果:MHD患者CRP水平显著高于对照组(P<0.05);微炎症组患者心脑血管疾病的发生率和总死亡率显著高于非炎症组(P<0.05);微炎症组患者血红蛋白(hemoglobin,Hb)、血浆白蛋白(albumin,ALB)、高密度脂蛋白胆固醇(high density lipoprotein cholestero,HDL-C)水平显著低于非炎症组,而低密度脂蛋白胆固醇(low density lipoprotein cholestero,LDL-C)水平显著高于非炎症组(均P<0.05);MHD患者LDL-C水平与CRP呈显著正相关(r=0.535,P<0.05),而Hb、ALB、HDL-C水平与CRP呈显著负相关(r=-0.418、-0.587、-0.552,均P<0.05)。结论:MHD患者的微炎症状态与心脑血管疾病的发生密切相关。
Objective:To investigate the relationship between C reactive protein(CRP)in hemodialysis patients and the development of cardiovascular disease.Methods:40 hemodialysis patients with uremia in Fourth People’s Hospital of Nantong were collected from July 2014 to July 2017 and divided into microinflammation group(n=20,CRP>6 mg/L)and non-microinflammation group(n=20,CRP≤6 mg/L).20 healthy people from the same time were termed as control group.Results:the CRP level in hemodialysis patients was higher than that in control group(P<0.05).The morbility and mortality of cardiovascular disease in microinflammation group were higher than that in the non-microinflammation group(P<0.05).The hemoglobin(Hb)and albumin(ALB)high density lipoprotein cholestero(HDL-C)in microinflammation group were higher compared with the non-microinflammation group and low density lipoprotein cholesterol(LDL-C)level were lower than that in non-microinflammation group(P<0.05).The LDL-C level in hemodialysis patients were significantly positive related with CRP level(r=0.535,P<0.05)and Hb,ALB,HDL-C in hemodialysis patients were significantly negative related with CRP(r=-0.418,-0.587,-0.552,all P<0.05).Conclusions:Microinflammation in hemodialysis patients were closely related with the development of cardiovacluar disease.
作者
钱慕周
陈澄
贾蔚
QIAN Muzhou;CHEN Cheng;JIA Wei(Blood Purification Center,the Fourth Hospital of People’s Nantong,Jiangsu Province,Nantong 226005)
出处
《南通大学学报（医学版）》
2017年第6期511-513,共3页
Journal of Nantong University(Medical sciences)
基金
南通市科技局社会事业科技创新与示范指令性课题(HS2014037)
关键词
尿毒症
血液透析
C反应蛋白
微炎症状态
心脑血管疾病
uremia
hemodialysis
C reactive protein
micro inflammation state
disease of heart head blood-vessel
