摘要
以二甲基丙烯酸乙二醇酯(EGDMA)为壁材单体、2-氰基-3,3-二苯基丙烯酸异辛酯(奥克立林,OCT)和辛酸/葵酸三甘油酯(GTCC)为芯材、过硫酸铵(APS)为引发剂,采用自由基界面聚合法制备防晒纳米胶囊。利用扫描电镜(SEM)、透射电子显微镜(TEM)、纳米粒度与电位分析仪(Nano-ZS)、红外光谱仪(FT-IR)、紫外线透过率分析仪等对防晒纳米胶囊的形貌、核-壳结构、粒径分布、化学组成和防晒性能进行表征。利用CCK-8法探究防晒纳米胶囊的生物相容性。结果表明:制得的防晒纳米胶囊为规整的球形,具有明显的核-壳结构,平均粒径为318nm,多分散系数为0.293;与未包覆OCT/GTCC的相比,防晒纳米胶囊具有更好的防晒性能,且降低了OCT对皮肤的刺激性,具有良好的生物相容性。
Suncream nanocapsules(NCs)loaded with Octocrylene(OCT)and caprylic/capric triglyceride(GTCC)were prepared by interfacial free-radical polymerization using ethylene glycol dimethacrylate(EGDMA)as monomer and ammonium persulfate(APS)as initiator.Morphology,core-shell structure,particle size distribution and chemical components of NCs were characterized by Scanning Electron Microscope(SEM),Transmission Electron Microscope(TEM),particle size&Zeta potential(Nano-ZS)analyzer and Fourier Transform Infrared(FT-IR)spectroscopy,respectively.And the Cell Counting Kit-8(CCK-8)assays were used to investigate the biocompatibility of suncream NCs.Besides,the prepared suncream NCs were added in reference cream to test its sun protect factor(SPF)by UV transmittance analyzer.Results of SEM showed that when the mass fraction of GTCC was 10%in the core materials,the NCs possessed spherical morphology.The analysis of FI-TR and the presence of core-shell structure illustrated that the core materials were encapsulated.And the average particle size of the optimized NCs was about 318 nm with a narrow polymer dispersity index(PDI=0.293).Compared to the cream with the non-encapsulated OCT/GTCC,the cream containing suncream NCs showed obviously higher SPF.Moreover,the result of CCK-8 indicated that the NCs could decrease the toxicity of OCT and possessed good biocompatibility.
作者
刘天群
赵迪
李雪婷
康园园
石小迪
鲁希华
LIU Tian-qun;ZHAO Di;LI Xue-ting;KANG Yuan-yuan;SHI Xiao-di;LU Xi-hua(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University, Shanghai 201620,Chin)
出处
《功能高分子学报》
CAS
CSCD
北大核心
2018年第2期175-180,共6页
Journal of Functional Polymers
基金
国家自然科学基金(51473032
51503034)
